Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | TTK | P33981 | 2/20 | 0.61 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.61 |
| ▸ | IDO1 | P14902 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | ALPL | P05186 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
| ▸ | FER | P16591 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | MARK3 | P27448 | 1/20 | 0.51 |
| ▸ | FLT4 | P35916 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL695357 | 0.83 | MAP2K4 (0.45) | ALDH1A1KDM4EHPGDTTKMAPK10 | |
| SCHEMBL27871836 | 0.82 | IDO1 (0.65) | TTKIDO1CLK2DYRK1AMAP2K4 | |
| SCHEMBL694710 | 0.81 | MAP2K4 (0.48) | ALDH1A1KDM4EHPGDTTKMAPK10 | |
| SCHEMBL699588 | 0.79 | MAP2K4 (0.54) | ALDH1A1KDM4EHPGDTTKMAPK10 | |
| SCHEMBL16937122 | 0.78 | IDO1 (0.71) | ALDH1A1KDM4EHPGDTTKMAPK10 | |
| SCHEMBL699881 | 0.78 | PIM1 (0.52) | KDM4EIDO1RAB9AMAPK9MAP2K4 | |
| SCHEMBL29211938 | 0.77 | PDGFRB (0.43) | ALDH1A1KDM4EHPGDTTKMAPK10 | |
| SCHEMBL855531 | 0.77 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDTTKMAPK10 | |
| SCHEMBL30768403 | 0.77 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDTTKMAPK10 | |
| SCHEMBL695280 | 0.76 | TRPA1 (0.52) | ALDH1A1KDM4EHPGDTTKMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421825-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica N.V. (BE) | 2012-02-29 | — | — | EP | claimed |
| WO-2010124108-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | claimed |
| EP-2421825-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica N.V. (BE) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010124108-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | disclosed |