Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.39 |
| ▸ | MELK | Q14680 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6947459 | 0.91 | TNF (0.52) | TNFHDAC1HDAC6HDAC8HDAC11 | |
| SCHEMBL6952964 | 0.86 | TNF (0.53) | TNFHDAC1HDAC6HDAC8HDAC11 | |
| SCHEMBL7530431 | 0.75 | PPARG (0.51) | — | |
| SCHEMBL17241737 | 0.73 | MAPT (0.63) | TNFHDAC1HDAC6HDAC8HDAC11 | |
| SCHEMBL6952391 | 0.72 | PPARG (0.46) | TNFHDAC1HDAC6HDAC8HDAC11 | |
| SCHEMBL6947495 | 0.71 | PPARA (0.46) | ALDH1A1 | |
| SCHEMBL6510771 | 0.70 | ERCC1 (0.60) | TNFHDAC1ALDH1A1TSHRERCC1 | |
| SCHEMBL17241665 | 0.70 | MAPT (0.56) | TNFHDAC1HDAC6HDAC8HDAC11 | |
| SCHEMBL6956161 | 0.70 | PPARG (0.46) | TNFHDAC1HDAC6HDAC8HDAC11 | |
| SCHEMBL6953729 | 0.70 | HTR1A (0.40) | HDAC1MAPTALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0903343-B1 | Alpha-Substituted phenylpropionic acid derivative and medicine containing the same | SSP CO LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| EP-0903343-A1 | Alpha-Substituted phenylpropionic acid derivative and medicine containing the same | SSP Co., Ltd. (JP) | 1999-03-24 | — | — | EP | disclosed |