Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | PRKCI | P41743 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17504841 | 0.86 | PRKCI (0.50) | CYP2A6FAAHPRKCILMNATP53 | |
| SCHEMBL6945218 | 0.80 | HTR7 (0.45) | HTR2AHTR2CHDAC8HTR7 | |
| SCHEMBL14945680 | 0.80 | CYP2A6 (0.53) | CYP2A6L3MBTL1FAAHPRKCIPIK3CB | |
| SCHEMBL8303438 | 0.79 | CYP2A6 (0.50) | CYP2A6L3MBTL1FAAHPRKCIPIK3CB | |
| SCHEMBL6947442 | 0.79 | CYP3A4 (0.47) | CYP2A6L3MBTL1FAAHTP53CA2 | |
| SCHEMBL6945213 | 0.78 | LMNA (0.37) | LMNATP53HTR2AHTR2CCA2 | |
| SCHEMBL25185804 | 0.78 | CYP2A6 (0.49) | CYP2A6L3MBTL1FAAHPRKCIPIK3CB | |
| SCHEMBL6583538 | 0.78 | CYP2A6 (0.49) | CYP2A6L3MBTL1FAAHPRKCIPIK3CB | |
| SCHEMBL111470 | 0.78 | CYP2A6 (0.49) | CYP2A6L3MBTL1FAAHPRKCIPIK3CB | |
| SCHEMBL14473327 | 0.78 | CYP2A6 (0.49) | CYP2A6L3MBTL1FAAHPRKCIPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1193027-C | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 2005-03-16 | — | — | CN | disclosed |
| CN-1151149-C | Substituted bisindolylmaleimides for inhibiting cell proliferation | - | 2004-05-26 | — | — | CN | disclosed |
| CN-1495182-A | Substituted diindolyl maleimide for inhibiting cell proliferation | - | 2004-05-12 | — | — | CN | disclosed |
| EP-0915872-B1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | HOFFMANN LA ROCHE (CH) | 2003-05-14 | — | — | EP | disclosed |
| CN-1411457-A | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 2003-04-16 | — | — | CN | disclosed |
| US-6281356-B1 | ANTICANRCER AGENTS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |
| US-6030994-A | ANTIPROLIFERATIVE, TUMOR AND CARCINOGENIC AGENTS; PARTICULARLY FOR TREATMENT OF SOLID TUMORS AND THOSE OF THE BREAST AND COLON | HOFFMANN-LA ROCHE INC. (US) | 2000-02-29 | — | — | US | disclosed |
| CN-1226247-A | Substituted bisindolylmaleimides for inhibiting cell proliferation | HOFFMANN LA ROCHE (CH) | 1999-08-18 | — | — | CN | disclosed |
| EP-0915872-A1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | F. HOFFMANN-LA ROCHE AG (CH) | 1999-05-19 | — | — | EP | disclosed |
| US-5856517-A | ANTIPROLIFERATIVE AGENTS USEFUL IN THE TREATMENT OF CANCER. | HOFFMANN-LA ROCHE INC. (US) | 1999-01-05 | — | — | US | disclosed |
| WO-1998004552-A1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | F. HOFFMANN-LA ROCHE AG (CH) | 1998-02-05 | — | — | WO | disclosed |