Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 3/20 | 0.42 |
| ▸ | MMP3 | P08254 | 3/20 | 0.42 |
| ▸ | MMP13 | P45452 | 3/20 | 0.42 |
| ▸ | MMP9 | P14780 | 2/20 | 0.42 |
| ▸ | FCER2 | P06734 | 1/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.32 |
| ▸ | MMP14 | P50281 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.31 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.31 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6946597 | 0.91 | MMP2 (0.35) | MMP2MMP3MMP13MMP9MMP14 | |
| SCHEMBL7478276 | 0.88 | MMP2 (0.37) | MMP2MMP3MMP13MMP9FCER2 | |
| SCHEMBL6949501 | 0.88 | MMP13 (0.33) | MMP2MMP3MMP13MMP9MMP14 | |
| SCHEMBL6952757 | 0.79 | MMP3 (0.48) | MMP2MMP3MMP13MMP9ADAM17 | |
| SCHEMBL6943124 | 0.77 | MMP2 (0.54) | MMP2MMP3MMP13MMP9ADAM17 | |
| SCHEMBL6943088 | 0.75 | MMP2 (0.49) | MMP2MMP3MMP13MMP9ADAM17 | |
| SCHEMBL6946816 | 0.75 | MMP13 (0.40) | MMP2MMP3MMP13MMP9ADAM17 | |
| SCHEMBL6949235 | 0.74 | MMP2 (0.43) | MMP2MMP3MMP13MMP9ADAM17 | |
| SCHEMBL6946800 | 0.73 | MMP2 (0.49) | MMP2MMP3MMP13MMP9ADAM17 | |
| SCHEMBL6947014 | 0.71 | MMP2 (0.49) | MMP2MMP3MMP13MMP9ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1030836-B1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY | DARWIN DISCOVERY LTD (GB) | 2003-01-29 | — | — | EP | claimed |
| US-6187924-B1 | INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TUMOR NECROSIS FACTOR-ALPHA-MEDIATED DISEASES | DARWIN DISCOVERY, LTD. (GB) | 2001-02-13 | — | — | US | claimed |