Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 8/20 | 0.39 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.39 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6943288 | 0.88 | TBXAS1 (0.42) | LMNA | |
| SCHEMBL6223932 | 0.83 | ADAM17 (0.45) | GRIK1GRIK2AAK1HTR2A | |
| SCHEMBL6220795 | 0.83 | ADAM17 (0.45) | GRIK1GRIK2AAK1HTR2A | |
| SCHEMBL6220562 | 0.83 | ADAM17 (0.45) | GRIK1GRIK2AAK1HTR2A | |
| SCHEMBL6224875 | 0.83 | ADAM17 (0.45) | GRIK1GRIK2AAK1HTR2A | |
| SCHEMBL6223927 | 0.83 | ADAM17 (0.45) | GRIK1GRIK2AAK1HTR2A | |
| SCHEMBL6224872 | 0.83 | ADAM17 (0.45) | GRIK1GRIK2AAK1HTR2A | |
| SCHEMBL6220793 | 0.83 | ADAM17 (0.45) | GRIK1GRIK2AAK1HTR2A | |
| SCHEMBL6220557 | 0.83 | ADAM17 (0.45) | GRIK1GRIK2AAK1HTR2A | |
| SCHEMBL7776166 | 0.83 | ADAM17 (0.45) | GRIK1GRIK2AAK1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |