Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6940502 | 0.99 | PABPC1 (0.42) | KMT2AL3MBTL1ALDH1A1MEN1POLB | |
| Hydrochloric Acid SCHEMBL6941540 | 0.86 | KMT2A (0.46) | KMT2AL3MBTL1ALDH1A1MEN1POLB | |
| Hydrochloric Acid SCHEMBL6946554 | 0.85 | SMN1; SMN2 (0.44) | KMT2AL3MBTL1ALDH1A1MEN1POLB | |
| SCHEMBL6942745 | 0.85 | KMT2A (0.43) | KMT2AL3MBTL1ALDH1A1MEN1POLB | |
| SCHEMBL6941688 | 0.84 | SMN1; SMN2 (0.45) | KMT2AL3MBTL1ALDH1A1MEN1POLB | |
| Hydrochloric Acid SCHEMBL6941749 | 0.81 | LMNA (0.47) | KMT2AL3MBTL1ALDH1A1MEN1POLB | |
| Hydrochloric Acid SCHEMBL6942172 | 0.81 | KMT2A (0.46) | KMT2AL3MBTL1ALDH1A1MEN1POLB | |
| Hydrochloric Acid SCHEMBL6942158 | 0.81 | PABPC1 (0.47) | KMT2AL3MBTL1ALDH1A1MEN1POLB | |
| Hydrochloric Acid SCHEMBL6943412 | 0.81 | POLB (0.47) | KMT2AL3MBTL1ALDH1A1POLBMAPT | |
| Hydrochloric Acid SCHEMBL6943286 | 0.80 | POLB (0.45) | KMT2AL3MBTL1ALDH1A1MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066022-B1 | COMPOSITIONS FOR OXIDATION DYEING KERATIN FIBRES COMPRISING A CATIONIC COUPLER, NOVEL CATIONIC COUPLERS, THEIR USE FOR OXIDATION DYEING AND DYEING METHODS | OREAL (FR) | 2003-10-22 | — | — | EP | claimed |
| US-6544298-B1 | Dyeing human hair using coupler | L'OREAL (FR) | 2003-04-08 | — | — | US | claimed |
| US-6537329-B1 | Intense colorations with a wide range of colours, excellent colorfastness | L'OREAL S.A. (FR) | 2003-03-25 | — | — | US | claimed |
| US-6544298-B1 | Dyeing human hair using coupler | L'OREAL (FR) | 2003-04-08 | — | — | US | disclosed |
| US-6537329-B1 | Intense colorations with a wide range of colours, excellent colorfastness | L'OREAL S.A. (FR) | 2003-03-25 | — | — | US | disclosed |