Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 5/20 | 0.56 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.32 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 3/20 | 0.32 |
| ▸ | CTSC | P53634 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 3/20 | 0.32 |
| ▸ | MMP3 | P08254 | 3/20 | 0.32 |
| ▸ | MMP7 | P09237 | 2/20 | 0.32 |
| ▸ | MMP1 | P03956 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6948137 | 0.93 | ADAM17 (0.55) | ADAM17GRIK1GRIK2HTR2ACTSC | |
| SCHEMBL6948147 | 0.93 | ADAM17 (0.55) | ADAM17GRIK1GRIK2HTR2ACTSC | |
| SCHEMBL6986274 | 0.89 | ADAM17 (0.52) | ADAM17GRIK1GRIK2MAPTMAPK1 | |
| SCHEMBL6945913 | 0.87 | ADAM17 (0.63) | ADAM17GRIK1GRIK2HTR2ACTSC | |
| SCHEMBL6943944 | 0.86 | ADAM17 (0.73) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL7935009 | 0.86 | ADAM17 (0.76) | ADAM17GRIK1GRIK2HTR2AMMP1 | |
| SCHEMBL6220502 | 0.82 | ADAM17 (0.48) | ADAM17GRIK1GRIK2HTR2ACTSC | |
| SCHEMBL6220493 | 0.82 | ADAM17 (0.48) | ADAM17GRIK1GRIK2HTR2ACTSC | |
| SCHEMBL6220496 | 0.82 | ADAM17 (0.48) | ADAM17GRIK1GRIK2HTR2ACTSC | |
| SCHEMBL6984686 | 0.82 | ADAM17 (0.48) | ADAM17GRIK1GRIK2HTR2ACTSC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |