Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 18/20 | 0.56 |
| ▸ | PTPRC | P08575 | 4/20 | 0.53 |
| ▸ | PTPN2 | P17706 | 4/20 | 0.52 |
| ▸ | PTPN6 | P29350 | 4/20 | 0.52 |
| ▸ | PTPRB | P23467 | 3/20 | 0.48 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.48 |
| ▸ | CDC25A | P30304 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6944073 | 0.90 | PTPN1 (0.67) | PTPN1PTPRCPTPN2PTPN6PTPRB | |
| SCHEMBL7886902 | 0.85 | PTPN1 (0.43) | PTPN1PTPRCPTPN2PTPN6CA2 | |
| SCHEMBL6946520 | 0.83 | PTPN1 (0.69) | PTPN1PTPRCPTPN2PTPN6PTPRB | |
| SCHEMBL7886903 | 0.82 | PTPN1 (0.41) | PTPN1PTPRCPTPN2PTPN6PTPRB | |
| SCHEMBL7888258 | 0.82 | PTPN1 (0.81) | PTPN1PTPRCPTPN2PTPN6PTPRB | |
| SCHEMBL6946043 | 0.81 | CA2 (0.45) | CA2CA12CA1CA4CA5A | |
| SCHEMBL6946012 | 0.75 | PTPN1 (0.80) | PTPN1PTPRC | |
| SCHEMBL6952150 | 0.71 | PTPN1 (1.00) | PTPN1PTPRCPTPN2PTPN6PTPRB | |
| SCHEMBL6946050 | 0.70 | PTPN1 (0.52) | PTPN1PTPRCPTPN2PTPN6PTPRB | |
| SCHEMBL6943717 | 0.69 | CA2 (0.38) | PTPRBCA2CA12CA1CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115729-B1 | PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PTP-1B | MERCK FROSST CANADA INC (CA) | 2003-02-19 | — | — | EP | claimed |
| US-6174874-B1 | ANTIDIABETIC,-CARCINOGENIC AGENTS; IMPROVING GLUCOSE TOLERANCE/INSULIN-SENSITIVITY; PREVENTING/TREATING OBESITY AND NEURODEGENERATIVE DISEASES; E.G. 1,3-BIS-((PHOSPHONODI-FLUOROMETHYL)PHENYL)-2-DICARBOXYPROPANE | MERCK FROSST CANADA & CO. (CA) | 2001-01-16 | — | — | US | claimed |
| EP-1115729-B1 | PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PTP-1B | MERCK FROSST CANADA INC (CA) | 2003-02-19 | — | — | EP | disclosed |
| US-6174874-B1 | ANTIDIABETIC,-CARCINOGENIC AGENTS; IMPROVING GLUCOSE TOLERANCE/INSULIN-SENSITIVITY; PREVENTING/TREATING OBESITY AND NEURODEGENERATIVE DISEASES; E.G. 1,3-BIS-((PHOSPHONODI-FLUOROMETHYL)PHENYL)-2-DICARBOXYPROPANE | MERCK FROSST CANADA & CO. (CA) | 2001-01-16 | — | — | US | disclosed |