Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.39 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 7/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | G6PD | P11413 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6947525 | 0.84 | ALDH1A1 (0.47) | ALDH1A1KDM4EGBA1HPGDABCC8 | |
| SCHEMBL5771980 | 0.82 | SQOR (0.38) | ALDH1A1KDM4EGBA1HPGDMAPT | |
| SCHEMBL25564157 | 0.78 | MAPT (0.40) | ALDH1A1KDM4EMAPTHSD17B10MEN1 | |
| SCHEMBL186585 | 0.78 | TRPV4 (0.52) | ALDH1A1KDM4EGBA1HPGDABCC8 | |
| SCHEMBL25564158 | 0.76 | NOTUM (0.40) | ALDH1A1KDM4EL3MBTL1LMNACYP1A2 | |
| SCHEMBL25564160 | 0.76 | ALDH1A1 (0.38) | ALDH1A1KDM4EMAPTHSD17B10MEN1 | |
| SCHEMBL3030161 | 0.75 | KDM4E (0.43) | ALDH1A1KDM4EGBA1HPGDMAPT | |
| SCHEMBL5774070 | 0.75 | ALDH1A1 (0.36) | ALDH1A1KDM4EGBA1HPGDABCC8 | |
| SCHEMBL31294594 | 0.74 | MAPT (0.50) | ALDH1A1ABCC8KCNJ11MAPTMEN1 | |
| SCHEMBL16838754 | 0.74 | CYP1A2 (0.47) | ALDH1A1KDM4EHPGDMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0887344-B1 | Quinolines and quinazolines useful in therapy | PFIZER LTD (GB) | 2003-12-03 | — | — | EP | disclosed |
| US-6417194-B1 | TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | PFIZER, INC. | 2002-07-09 | — | — | US | disclosed |
| US-6048864-A | Quinolines and quinazolines useful in therapy | PFIZER INC (US) | 2000-04-11 | — | — | US | disclosed |
| EP-0887344-A1 | Quinolines and quinazolines useful in therapy | Pfizer Limited (GB) | 1998-12-30 | — | — | EP | disclosed |