Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | HK1 | P19367 | 1/20 | 0.35 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8803444 | 0.84 | CREBBP (0.47) | ALDH1A1KDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL273000 | 0.83 | L3MBTL1 (0.63) | L3MBTL1MEN1KMT2APOLBEPHX1 | |
| SCHEMBL4518718 | 0.82 | STAT3 (0.42) | L3MBTL1PRMT5OXER1ALDH1A1KDM4E | |
| SCHEMBL19358619 | 0.79 | HTR2A (0.55) | L3MBTL1OXER1ALDH1A1KDM4E | |
| SCHEMBL26134474 | 0.78 | OXER1 (0.54) | L3MBTL1OXER1ALDH1A1KDM4EMEN1 | |
| SCHEMBL30936109 | 0.77 | HTR6 (0.54) | — | |
| SCHEMBL7080367 | 0.75 | L3MBTL1 (0.48) | L3MBTL1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL28477612 | 0.74 | TFPI2 (0.47) | L3MBTL1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL7166755 | 0.74 | TACR3 (0.51) | L3MBTL1ALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL28567995 | 0.73 | KMT2A (0.46) | L3MBTL1ALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1127500-C | Substituted bisindolylmaleimides for inhibiting cell proliferation | HOFFMANN LA ROCHE (CH) | 2003-11-12 | — | — | CN | disclosed |
| EP-1064279-B1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | HOFFMANN LA ROCHE (CH) | 2003-06-25 | — | — | EP | disclosed |
| CN-1293671-A | Substituted bisindolymaleimides for inhibition of cell proliferation | HOFFMANN LA ROCHE (CH) | 2001-05-02 | — | — | CN | disclosed |
| EP-1064279-A1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | F.HOFFMANN-LA ROCHE AG (CH) | 2001-01-03 | — | — | EP | disclosed |
| US-6048887-A | 3-(1H-INDOL-3-YL)-4-(1-METHYL-6-NITRO-1H-INDOL-3-YL)-PYRROLE-2,5 -DIONE(AND OTHER DERIVATIVES) AS ANTICARCINOGENIC, ANTITUMOR OR ANTIPROLIFERATIVE AGENTS | HOFFMANN-LA ROCHE INC. (US) | 2000-04-11 | — | — | US | disclosed |
| WO-1999047518-A1 | SUBSTITUTED BISINDOLYMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | F. HOFFMANN-LA ROCHE AG (CH) | 1999-09-23 | — | — | WO | disclosed |