Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | LAP3 | P28838 | 3/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | ANPEP | P15144 | 3/20 | 0.32 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | GABBR2 | O75899 | 2/20 | 0.31 |
| ▸ | GABBR1 | Q9UBS5 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphoric Acid SCHEMBL27767980 | 0.86 | SLC34A1 (0.53) | SLC34A1LMNAALDH1A1CA2LAP3 | |
| Phosphoric Acid SCHEMBL6906000 | 0.85 | SLC34A1 (0.50) | SLC34A1LMNAALDH1A1CA2LAP3 | |
| Phosphoric Acid SCHEMBL27995441 | 0.83 | SLC34A1 (0.50) | SLC34A1LMNAALDH1A1CA2LAP3 | |
| Propylene Glycol SCHEMBL27676897 | 0.82 | TDP1 (0.56) | SLC34A1ALDH1A1LAP3ANPEPERAP1 | |
| Phosphoric Acid SCHEMBL27518794 | 0.82 | SLC34A1 (0.50) | SLC34A1LMNAALDH1A1CA2LAP3 | |
| Phosphoric Acid SCHEMBL28353739 | 0.81 | LMNA (0.46) | SLC34A1LMNAALDH1A1CA2LAP3 | |
| Phosphoric Acid SCHEMBL29090802 | 0.81 | LMNA (0.46) | SLC34A1LMNAALDH1A1CA2LAP3 | |
| Phosphoric Acid SCHEMBL5479745 | 0.81 | ALDH1A1 (0.55) | LMNAALDH1A1CA2LAP3CA12 | |
| Phosphoric Acid SCHEMBL3869841 | 0.81 | — | — | |
| Phosphoric Acid SCHEMBL28218504 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106946692-B | A method of using ketoglutaric acid in aqueous two-phase extraction fermentation liquid | 四川理工学院 | 2019-06-18 | — | — | CN | claimed |
| CN-106946692-B | A method of using ketoglutaric acid in aqueous two-phase extraction fermentation liquid | 四川理工学院 | 2019-06-18 | — | — | CN | disclosed |
| CN-106946692-A | A kind of method of ketoglutaric acid in use aqueous two-phase extraction zymotic fluid | 四川理工学院 | 2017-07-14 | — | — | CN | disclosed |
| EP-1351960-A1 | IMPROVED PREPARATION OF (4R, 5S, 6S)-3-[[(2R,3R)-2-[[[(S)-2-AMINO-3-METHYL-1-OXOBUTYL]METHYL]TETRAHYDRO-3-FURANYL]THIO]-6-[(R)-1-HYDROXYETHYL]-4-METHYL-7-OXO-1-AZABICYCLO[3.2.0]HEPT-2-ENE-2-CARBOXYLIC ACID | Wyeth (US) | 2003-10-15 | — | — | EP | disclosed |
| WO-2002006283-A1 | IMPROVED PREPARATION OF (4R, 5S, 6S)-3-(((2R,3R)-2-((((S)-2-AMINO-3-METHYL-1-OXOBUTYL)METHYL)TETRAHYDRO-3-FURANYL)THIO)-6-((R)-1-HYDROXYETHYL)-4-METHYL-7-OXO-1-AZABICYCLO(3.2.0)HEPT-2-ENE-2-CARBOXYLIC ACID | WYETH (US) | 2002-01-24 | — | — | WO | disclosed |
| EP-0478874-A2 | Novel 2-substituted alkyl-3-carboxy carbapenems as antibiotics and a method of producing them | AMERICAN CYANAMID COMPANY (US) | 1992-04-08 | — | — | EP | disclosed |
| EP-0062840-B1 | PROCESS FOR THE PREPARATION OF (2S)-TETRAHYDRO-2ALPHA-METHYL-6-OXO-4BETA-AMINO-2H-PYRAN-3ALPHA-CARBOXYLIC ACID ESTERS | MERCK & CO. INC. (US) | 1987-12-16 | — | — | EP | disclosed |
| EP-0235823-A2 | Carbapenem antibiotics, a process for preparing them and pharmaceutical compositions containing them | Bristol-Myers Squibb Company (US) | 1987-09-09 | — | — | EP | disclosed |
| US-4344885-A | Intermediate for the preparation of thienamycin | MERCK & CO., INC. (US) | 1982-08-17 | — | — | US | disclosed |
| US-4341791-A | 6-, 2- and 1,1-Disubstituted-1-carbadethiapen-2-em-3-carboxylic acid S-oxides | MERCK & CO., INC. (US) | 1982-07-27 | — | — | US | disclosed |
| EP-0032400-A1 | (3SR, 4RS)-3-((RS)-1-hydroxyethyl)- and -((RS)-1-acyloxyethyl)-2-oxo-4-azetidineacetic acid compounds and a process for preparing the same | MERCK & CO. INC. (US) | 1981-07-22 | — | — | EP | disclosed |