Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.53 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.53 |
| ▸ | CTSL | P07711 | 2/20 | 0.52 |
| ▸ | CTSS | P25774 | 2/20 | 0.52 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 8/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 6/20 | 0.49 |
| ▸ | ITGAV | P06756 | 2/20 | 0.48 |
| ▸ | TGM2 | P21980 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 3/20 | 0.48 |
| ▸ | MME | P08473 | 1/20 | 0.48 |
| ▸ | ECE1 | P42892 | 1/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8671689 | 1.00 | SIRT2 (0.53) | SIRT2SIRT1CTSLCTSSFOLH1 | |
| SCHEMBL26641013 | 0.96 | SIRT2 (0.55) | SIRT2SIRT1CTSLCTSSFOLH1 | |
| SCHEMBL26641008 | 0.96 | SIRT2 (0.55) | SIRT2SIRT1CTSLCTSSFOLH1 | |
| SCHEMBL28723314 | 0.93 | CTSK (0.50) | SIRT2SIRT1CTSLCTSSFOLH1 | |
| SCHEMBL28723315 | 0.93 | CTSK (0.50) | SIRT2SIRT1CTSLCTSSFOLH1 | |
| SCHEMBL9301974 | 0.88 | SYK (0.52) | SIRT2SIRT1CTSLCTSSITGB3 | |
| SCHEMBL4972916 | 0.85 | CTSK (0.52) | CTSLCTSSITGB3ITGA2BCTSK | |
| SCHEMBL4972907 | 0.85 | CTSK (0.52) | CTSLCTSSITGB3ITGA2BCTSK | |
| SCHEMBL5141850 | 0.85 | CTRB1 (0.49) | CTSLCTSSCTSKCTSB | |
| SCHEMBL5141853 | 0.85 | CTRB1 (0.49) | CTSLCTSSCTSKCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0758328-B1 | ANTI-CANCER COMPOUNDS CONTAINING CYCLOPENTAQUINAZOLINE RING | BTG INT LTD (GB) | 2003-07-16 | — | — | EP | disclosed |
| US-5747499-A | CYCLOPENTAQUINAZOLINE COMPOUNDS CYCLOPENTAQUINAZOLINE COMPOUNDS | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1998-05-05 | — | — | US | disclosed |
| EP-0758328-A1 | ANTI-CANCER COMPOUNDS CONTAINING CYCLOPENTAQUINAZOLINE RING | BTG INTERNATIONAL LIMITED (GB) | 1997-02-19 | — | — | EP | disclosed |
| WO-1995030673-A1 | ANTI-CANCER COMPOUNDS CONTAINING CYCLOPENTAQUINAZOLINE RING | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1995-11-16 | — | — | WO | disclosed |