Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6944230 | 0.91 | ADAM17 (0.40) | ADAM17TSHR | |
| SCHEMBL6947526 | 0.81 | ADAM17 (0.47) | ADAM17POLBTSHRMEN1KMT2A | |
| SCHEMBL6947013 | 0.74 | MMP1 (0.52) | ADAM17 | |
| SCHEMBL6940005 | 0.69 | ADAM17 (0.41) | ADAM17POLBMEN1KMT2A | |
| SCHEMBL6942476 | 0.65 | ADAM17 (0.45) | ADAM17 | |
| SCHEMBL16415924 | 0.59 | SMN1; SMN2 (0.38) | ADAM17TSHRMEN1KMT2A | |
| SCHEMBL30093936 | 0.58 | EPHX1 (0.44) | — | |
| SCHEMBL10879040 | 0.58 | ATM (0.41) | — | |
| SCHEMBL5512591 | 0.58 | SMN1; SMN2 (0.43) | — | |
| SCHEMBL5519131 | 0.58 | SMN1; SMN2 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |