Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.47 |
| ▸ | ERCC5 | P28715 | 4/20 | 0.47 |
| ▸ | FEN1 | P39748 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27715515 | 0.84 | HTT (0.56) | GAARAB9APOLBHIF1AEPAS1 | |
| SCHEMBL6950593 | 0.76 | FEN1 (0.57) | RAB9ASMN1; SMN2PTPN1ERCC5FEN1 | |
| SCHEMBL7665649 | 0.76 | ERCC5 (0.56) | RAB9APOLBSMN1; SMN2PTPN1ERCC5 | |
| SCHEMBL7667737 | 0.74 | GRM2 (0.57) | GAARAB9ASMN1; SMN2PTPN1ERCC5 | |
| SCHEMBL3322508 | 0.73 | LMNA (0.61) | GAARAB9APOLBSMN1; SMN2HTT | |
| SCHEMBL6948181 | 0.72 | PTPN1 (0.61) | RAB9ASMN1; SMN2PTPN1ERCC5FEN1 | |
| SCHEMBL28857585 | 0.72 | LMNA (0.66) | GAARAB9APOLBHIF1AEPAS1 | |
| SCHEMBL28857605 | 0.72 | HIF1A (0.60) | GAARAB9APOLBHIF1AEPAS1 | |
| SCHEMBL28857591 | 0.72 | HIF1A (0.60) | GAARAB9APOLBHIF1AEPAS1 | |
| Dimethylamine SCHEMBL6946035 | 0.72 | PTPN1 (0.68) | PTPN1ERCC5FEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082121-A4 | HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2003-02-05 | — | — | EP | claimed |
| US-6380249-B1 | HIV integrase inhibitors | MERCK & CO., INC. | 2002-04-30 | — | — | US | claimed |
| EP-1082121-A1 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2001-03-14 | — | — | EP | claimed |
| WO-1999062520-A1 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | claimed |
| EP-1082121-A4 | HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2003-02-05 | — | — | EP | disclosed |
| US-6380249-B1 | HIV integrase inhibitors | MERCK & CO., INC. | 2002-04-30 | — | — | US | disclosed |
| EP-1082121-A1 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999062520-A1 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | disclosed |