Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 7/20 | 0.56 |
| ▸ | FEN1 | P39748 | 7/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HAO1 | Q9UJM8 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7671810 | 0.84 | CYP19A1 (0.46) | ERCC5FEN1PTPN1CYP19A1HAO1 | |
| SCHEMBL6950593 | 0.84 | FEN1 (0.57) | ERCC5FEN1PTPN1HAO1HDAC1 | |
| SCHEMBL7077546 | 0.76 | ACKR3 (0.40) | CYP19A1HTTHDAC1HDAC6NPC1 | |
| SCHEMBL6940911 | 0.76 | PTPN1 (0.72) | ERCC5FEN1PTPN1HAO1TDP1 | |
| SCHEMBL7196671 | 0.76 | ERCC5 (0.66) | ERCC5FEN1PTPN1HAO1TDP1 | |
| SCHEMBL6947108 | 0.76 | GAA (0.52) | ERCC5FEN1PTPN1HTTPOLB | |
| SCHEMBL6948009 | 0.74 | PTPN1 (0.57) | ERCC5FEN1PTPN1HAO1 | |
| SCHEMBL7662930 | 0.74 | CYP11B1 (0.58) | PTPN1HDAC1HDAC6L3MBTL1SMN1; SMN2 | |
| SCHEMBL7667737 | 0.74 | GRM2 (0.57) | ERCC5FEN1PTPN1NPC1RAB9A | |
| Dimethylamine SCHEMBL6946035 | 0.74 | PTPN1 (0.68) | ERCC5FEN1PTPN1HAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380249-B1 | HIV integrase inhibitors | MERCK & CO., INC. | 2002-04-30 | — | — | US | claimed |
| US-6380249-B1 | HIV integrase inhibitors | MERCK & CO., INC. | 2002-04-30 | — | — | US | disclosed |