Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 2/20 | 0.36 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.33 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6942710 | 0.88 | ADAM17 (0.46) | ADAM17GAAMMP1MMP2MMP9 | |
| SCHEMBL6942460 | 0.84 | ADAM17 (0.46) | ADAM17MMP1MMP2MAPK1GRIK1 | |
| SCHEMBL6944086 | 0.83 | ADAM17 (0.42) | ADAM17GAAMMP1MMP2MMP9 | |
| SCHEMBL6220497 | 0.83 | ADAM17 (0.48) | ADAM17TDP1MAPK1GRIK1GRIK2 | |
| SCHEMBL6986484 | 0.83 | ADAM17 (0.48) | ADAM17TDP1MAPK1GRIK1GRIK2 | |
| SCHEMBL6984686 | 0.83 | ADAM17 (0.48) | ADAM17TDP1MAPK1GRIK1GRIK2 | |
| SCHEMBL6220493 | 0.83 | ADAM17 (0.48) | ADAM17TDP1MAPK1GRIK1GRIK2 | |
| SCHEMBL6220502 | 0.83 | ADAM17 (0.48) | ADAM17TDP1MAPK1GRIK1GRIK2 | |
| SCHEMBL6220496 | 0.83 | ADAM17 (0.48) | ADAM17TDP1MAPK1GRIK1GRIK2 | |
| SCHEMBL6219850 | 0.82 | ADAM17 (0.46) | ADAM17GRIK1GRIK2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |