Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.32 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.31 |
| ▸ | SCN1A | P35498 | 1/20 | 0.31 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.31 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 3/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6943069 | 0.91 | CCR3 (0.35) | CCR3KDM4EALDH1A1BDKRB1MAPK1 | |
| SCHEMBL6152139 | 0.91 | CCR3 (0.35) | CCR3KDM4EALDH1A1BDKRB1MAPK1 | |
| SCHEMBL6948042 | 0.91 | RXFP1 (0.35) | CCR3KDM4EALDH1A1BDKRB1MGLL | |
| SCHEMBL7493254 | 0.91 | SIGMAR1 (0.41) | CCR3KDM4EALDH1A1BDKRB1MGLL | |
| SCHEMBL6154279 | 0.89 | CCR3 (0.33) | CCR3KDM4EALDH1A1BDKRB1MAPK1 | |
| SCHEMBL7132284 | 0.89 | LMNA (0.35) | ALDH1A1MGLLTP53CHRM2 | |
| SCHEMBL6153116 | 0.88 | CCR3 (0.33) | CCR3BDKRB1MAPK1AVPR1A | |
| SCHEMBL6942959 | 0.87 | SIGMAR1 (0.35) | CCR3BDKRB1 | |
| SCHEMBL6943352 | 0.87 | MAPK1 (0.35) | CCR3KDM4EALDH1A1BDKRB1MAPK1 | |
| SCHEMBL6152340 | 0.87 | HTR1A (0.38) | CCR3BDKRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6653313-B2 | For treatment and prevention of inflammation, asthma, allergic rhinitis, pain and other disorders | WARNER-LAMBERT COMPANY LLC | 2003-11-25 | — | — | US | disclosed |
| EP-1307449-A1 | 1,4-DIHYDROPYRIDINES AS BRADYKININ ANTAGONISTS | PFIZER PHARMACEUTICALS INC. (JP) | 2003-05-07 | — | — | EP | disclosed |
| WO-2002012235-A1 | 1,4-DIHYDROPYRIDINES AS BRADYKININ ANTAGONISTS | PFIZER PHARMACEUTICALS INC. (JP) | 2002-02-14 | — | — | WO | disclosed |