SCHEMBL6947235

SCHEMBL6947235

COC(=O)C[C@@](O)(CC(C)C)C(=O)OC

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
USP2 O75604 1/20 0.39
LMNA P02545 1/20 0.39
CA12 O43570 1/20 0.35
CA7 P43166 1/20 0.35
CA9 Q16790 1/20 0.35
CA14 Q9ULX7 1/20 0.35
MMP8 P22894 1/20 0.35
MAPT P10636 1/20 0.35
TSHR P16473 3/20 0.34
HSD17B10 Q99714 2/20 0.33
RECQL P46063 2/20 0.33
MEN1 O00255 1/20 0.33
HPGD P15428 1/20 0.33
KMT2A Q03164 1/20 0.33
MGAM O43451 1/20 0.32
SI P14410 1/20 0.32
MGAM2 Q2M2H8 1/20 0.32
TET2 Q6N021 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14600621 0.85 MAPT (0.40) GAASMN1; SMN2USP2LMNACA12
SCHEMBL13059735 0.85 MAPT (0.40) GAASMN1; SMN2USP2LMNACA12
SCHEMBL168730 0.83 TSHR (0.43) GAAUSP2LMNACA12CA14
SCHEMBL22433277 0.83 GAA (0.35) GAASMN1; SMN2USP2LMNACA12
SCHEMBL16254847 0.81 L3MBTL1 (0.41) GAAUSP2LMNACA12CA7
Methoxymethane SCHEMBL28184894 0.81 TSHR (0.42) GAAUSP2LMNACA12CA14
Ammonia Solution, Strong SCHEMBL28166385 0.81 TSHR (0.42) GAAUSP2LMNACA12CA14
SCHEMBL5611565 0.80 GAA (0.38) GAASMN1; SMN2MMP8MAPTCYP2C19
SCHEMBL28963017 0.78 USP2 (0.36) GAAUSP2LMNACA12CA7
SCHEMBL1812866 0.78 TSHR (0.39) GAAUSP2LMNATSHRHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1030842-B1 METALLOPROTEINASE INHIBITORS BRITISH BIOTECH PHARM (GB) 2003-04-02 EP disclosed
EP-0835240-B1 MATRIX METALLOPROTEINASE INHIBITORS BRITISH BIOTECH PHARM (GB) 2000-11-02 EP disclosed
EP-1030842-A1 METALLOPROTEINASE INHIBITORS BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) 2000-08-30 EP disclosed
EP-0821668-B1 DERIVATIVES OF SUCCINAMIDE AND THEIR USE AS METALLOPROTEINASE INHIBITOR BRITISH BIOTECH PHARM (GB) 2000-08-23 EP disclosed
US-5919940-A TERT-LEUCINE-THIAZOL-2-YLAMIDE BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) 1999-07-06 US disclosed
US-5917090-A INHIBIT TUMOR NECROSIS FACTOR; ANTIARTHRITIC AGENTS BRITISH BIOTECH PHARMACEUTICALS LTD. (GB) 1999-06-29 US disclosed
US-5908851-A TUMOR NECROSIS FACTOR, COLLAGENASE, STROMELYSIN, AND GELATINASE INHIBITORS; OSTEOPOROSIS, RHEUMATIC AND ORAL DISEASES; ANTIARTHRITIC AND ANTIULCER AGENTS BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) 1999-06-01 US disclosed
WO-1999025693-A1 METALLOPROTEINASE INHIBITORS BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) 1999-05-27 WO disclosed
US-5859253-A L-TERT-LEUCINE-2-PYRIDYLAMIDE BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) 1999-01-12 US disclosed
US-5747514-A Metalloproteinase inhibitors BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) 1998-05-05 US disclosed
EP-0835240-A1 MATRIX METALLOPROTEINASE INHIBITORS BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) 1998-04-15 EP disclosed
EP-0821668-A1 DERIVATIVES OF SUCCINAMIDE AND THEIR USE AS METALLOPROTEINASE INHIBITOR BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) 1998-02-04 EP disclosed
WO-1997003966-A1 N-(AMINO ACID) SUBSTITUTED SUCCINIC ACID AMIDE DERIVATIVES AS METALLOPROTEINASE INHIBITORS BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) 1997-02-06 WO disclosed
WO-1997002239-A1 MATRIX METALLOPROTEINASE INHIBITORS BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) 1997-01-23 WO disclosed
WO-1996033165-A1 DERIVATIVES OF SUCCINAMIDE AND THEIR USE AS METALLOPROTEINASE INHIBITOR BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) 1996-10-24 WO disclosed