Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8782641 | 0.85 | SLC6A3 (0.46) | KDM4CSLC6A3KCNA5SCN5ANPC1 | |
| SCHEMBL8971968 | 0.84 | SLC6A3 (0.42) | KDM4CSLC6A3MCHR1KCNA5SCN5A | |
| Hydrochloric Acid SCHEMBL8369516 | 0.84 | SLC6A3 (0.45) | KDM4CSLC6A3NPC1RAB9ASLC6A2 | |
| SCHEMBL8592474 | 0.83 | SLC6A3 (0.44) | KDM4CSLC6A3NPC1RAB9ASLC6A2 | |
| SCHEMBL5866431 | 0.82 | MCHR1 (0.44) | SLC6A3MCHR1SSTR3SLC6A2SLC6A4 | |
| SCHEMBL5858706 | 0.80 | SLC6A3 (0.42) | KDM4CSLC6A3KCNA5SCN5ANPC1 | |
| SCHEMBL6579345 | 0.80 | SLC6A3 (0.45) | KDM4CSLC6A3KCNA5SCN5ANPC1 | |
| SCHEMBL8974538 | 0.80 | MCHR1 (0.44) | SLC6A3MCHR1SLC6A2 | |
| SCHEMBL7305694 | 0.79 | SLC6A3 (0.44) | KDM4CSLC6A3KCNA5SCN5ANPC1 | |
| SCHEMBL9053699 | 0.78 | SLC6A3 (0.44) | KDM4CSLC6A3KCNA5SCN5ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709376-B1 | Phenylpiperidino derivatives as neurokinin antagonists | ASTRAZENECA AB (SE) | 2003-07-23 | — | — | EP | disclosed |
| US-6008223-A | ANTIINFLAMMATORY AGENTS FOR TREATING ASTHMA | ZENECA LIMITED (GB) | 1999-12-28 | — | — | US | disclosed |
| US-5731309-A | Substituted heteroalkyleneamine neurokinin antagonists | ZENECA LIMITED (GB) | 1998-03-24 | — | — | US | disclosed |
| EP-0709376-A2 | Therapeutic compounds | ZENECA LIMITED (GB) | 1996-05-01 | — | — | EP | disclosed |