Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR3 | P49682 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.33 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 4/20 | 0.32 |
| ▸ | BUB1 | O43683 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6262597 | 0.83 | MAP2K1 (0.43) | CXCR3MAP2K1NAMPTALDH1A1MEN1 | |
| SCHEMBL6263499 | 0.82 | MAP2K1 (0.43) | CXCR3MAP2K1PDE4APDE4BPDE4C | |
| SCHEMBL7112501 | 0.82 | BUB1 (0.32) | BUB1 | |
| SCHEMBL6262626 | 0.81 | CXCR3 (0.46) | CXCR3MAP2K1PDE4APDE4BPDE4C | |
| SCHEMBL6262380 | 0.79 | CXCR3 (0.41) | CXCR3MAP2K1PDE4APDE4BPDE4C | |
| SCHEMBL7459563 | 0.78 | TDP1 (0.40) | CXCR3MAP2K1PDE4APDE4BPDE4C | |
| SCHEMBL7118232 | 0.78 | CXCR3 (0.35) | CXCR3NAMPTADRB2ALDH1A1KMT2A | |
| SCHEMBL7118222 | 0.76 | MEN1 (0.41) | MAP2K1ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL6261409 | 0.76 | MAP2K1 (0.57) | CXCR3MAP2K1ALDH1A1MEN1KMT2A | |
| SCHEMBL6260593 | 0.76 | MAP2K1 (0.56) | CXCR3MAP2K1NAMPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202724-B1 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER LAMBERT CO (US) | 2003-10-01 | — | — | EP | disclosed |
| EP-1202724-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001005393-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-01-25 | — | — | WO | disclosed |