Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BUB1 | O43683 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7118222 | 0.89 | MEN1 (0.41) | — | |
| SCHEMBL7783692 | 0.83 | HDAC6 (0.37) | BUB1 | |
| SCHEMBL7118232 | 0.82 | CXCR3 (0.35) | JAK2JAK1SYK | |
| SCHEMBL6947384 | 0.82 | CXCR3 (0.36) | BUB1 | |
| SCHEMBL6261631 | 0.78 | MEN1 (0.47) | — | |
| SCHEMBL6262597 | 0.75 | MAP2K1 (0.43) | — | |
| SCHEMBL7122977 | 0.75 | NAMPT (0.35) | BUB1JAK2JAK1 | |
| SCHEMBL6264267 | 0.75 | MEN1 (0.45) | — | |
| SCHEMBL7112487 | 0.74 | FABP4 (0.40) | BUB1SYK | |
| SCHEMBL7118932 | 0.74 | KMT2A (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2003504401-A | — | — | 2003-02-04 | — | — | JP | claimed |
| EP-1202724-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2002-05-08 | — | — | EP | claimed |
| WO-2001005393-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-01-25 | — | — | WO | claimed |