Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR3 | P49682 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 7/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 2/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7118932 | 0.90 | KMT2A (0.37) | CXCR3NAMPTUSP2ALDH1A1KDM4E | |
| SCHEMBL7120943 | 0.85 | CXCR3 (0.34) | CXCR3NAMPTUSP2RORCALDH1A1 | |
| SCHEMBL7112501 | 0.82 | BUB1 (0.32) | JAK2JAK1SYK | |
| SCHEMBL6263086 | 0.81 | MEN1 (0.42) | CXCR3NAMPTRORCALDH1A1KDM4E | |
| SCHEMBL6262380 | 0.78 | CXCR3 (0.41) | CXCR3NAMPTUSP2RORCALDH1A1 | |
| SCHEMBL6947384 | 0.78 | CXCR3 (0.36) | CXCR3NAMPTALDH1A1ADRB2LMNA | |
| SCHEMBL7459563 | 0.77 | TDP1 (0.40) | CXCR3NAMPTUSP2GAAF2 | |
| SCHEMBL7122977 | 0.76 | NAMPT (0.35) | CXCR3NAMPTJAK2JAK1USP2 | |
| SCHEMBL7645897 | 0.74 | HDAC3 (0.40) | CXCR3NAMPTALDH1A1LMNAKMT2A | |
| SCHEMBL7118222 | 0.74 | MEN1 (0.41) | ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2003504401-A | — | — | 2003-02-04 | — | — | JP | claimed |
| EP-1202724-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2002-05-08 | — | — | EP | claimed |
| WO-2001005393-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-01-25 | — | — | WO | claimed |