Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 6/20 | 0.49 |
| ▸ | MMP14 | P50281 | 4/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.44 |
| ▸ | FPR2 | P25090 | 1/20 | 0.43 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.43 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | RORA | P35398 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6950104 | 0.90 | MMP13 (0.47) | MMP13MMP14HRH3FPR2PROKR1 | |
| SCHEMBL6952614 | 0.87 | MMP13 (0.52) | MMP13MMP14HRH3FPR2PROKR1 | |
| SCHEMBL6943119 | 0.87 | MMP13 (0.52) | MMP13MMP14HRH3FPR2PROKR1 | |
| SCHEMBL6943318 | 0.82 | ADAM10 (0.59) | MMP13MMP14ADAM10MMP2 | |
| SCHEMBL6943142 | 0.81 | HRH3 (0.49) | MMP13MMP14HRH3FPR2PROKR1 | |
| SCHEMBL6954248 | 0.75 | MMP13 (0.47) | MMP13MMP14HRH3FPR2PROKR1 | |
| SCHEMBL6948792 | 0.73 | MMP13 (0.56) | MMP13MMP14HRH3FPR2PROKR1 | |
| SCHEMBL2706929 | 0.73 | HRH3 (0.56) | MMP13MMP14HRH3FPR2PROKR1 | |
| SCHEMBL6035783 | 0.71 | MMP13 (0.58) | MMP13MMP14FPR2PROKR1MMP2 | |
| SCHEMBL13596766 | 0.70 | MMP13 (0.88) | MMP13MMP14MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1030836-B1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY | DARWIN DISCOVERY LTD (GB) | 2003-01-29 | — | — | EP | claimed |