Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM10 | O14672 | 14/20 | 0.59 |
| ▸ | MMP2 | P08253 | 13/20 | 0.59 |
| ▸ | MMP13 | P45452 | 5/20 | 0.50 |
| ▸ | MMP14 | P50281 | 2/20 | 0.50 |
| ▸ | MMP3 | P08254 | 6/20 | 0.48 |
| ▸ | MMP9 | P14780 | 6/20 | 0.48 |
| ▸ | MMP1 | P03956 | 4/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | MMP7 | P09237 | 1/20 | 0.44 |
| ▸ | MMP10 | P09238 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6943119 | 0.90 | MMP13 (0.52) | ADAM10MMP2MMP13MMP14 | |
| SCHEMBL6950652 | 0.88 | MMP2 (0.58) | ADAM10MMP2MMP13MMP14MMP3 | |
| SCHEMBL6950104 | 0.85 | MMP13 (0.47) | ADAM10MMP2MMP13MMP14MMP1 | |
| SCHEMBL6943142 | 0.85 | HRH3 (0.49) | ADAM10MMP2MMP13MMP14 | |
| SCHEMBL6035791 | 0.85 | MMP13 (0.53) | ADAM10MMP2MMP13MMP14MMP3 | |
| SCHEMBL6947588 | 0.82 | MMP13 (0.49) | ADAM10MMP2MMP13MMP14 | |
| SCHEMBL6036512 | 0.79 | MMP2 (0.51) | ADAM10MMP2MMP13MMP14MMP3 | |
| SCHEMBL6954248 | 0.78 | MMP13 (0.47) | ADAM10MMP2MMP13MMP14 | |
| SCHEMBL6948792 | 0.77 | MMP13 (0.56) | MMP2MMP13MMP14MMP3MMP9 | |
| SCHEMBL6360590 | 0.75 | ADAM10 (1.00) | ADAM10MMP2MMP3MMP9MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1030836-B1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY | DARWIN DISCOVERY LTD (GB) | 2003-01-29 | — | — | EP | claimed |