Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | F7 | P08709 | 1/20 | 0.54 |
| ▸ | F3 | P13726 | 1/20 | 0.54 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.54 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.54 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.54 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.54 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.54 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.54 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6947970 | 1.00 | ALDH1A1 (0.58) | ALDH1A1F7F3SARM1SIRT2 | |
| SCHEMBL29105669 | 1.00 | ALDH1A1 (0.58) | ALDH1A1F7F3SARM1SIRT2 | |
| SCHEMBL29882651 | 1.00 | ALDH1A1 (0.58) | ALDH1A1F7F3SARM1SIRT2 | |
| SCHEMBL7916715 | 0.84 | F7 (0.50) | ALDH1A1F7F3SARM1SIRT2 | |
| SCHEMBL6629937 | 0.84 | F7 (0.50) | ALDH1A1F7F3SARM1SIRT2 | |
| SCHEMBL2279497 | 0.83 | ALDH1A1 (0.60) | ALDH1A1F7F3SARM1SIRT2 | |
| SCHEMBL2279492 | 0.83 | ALDH1A1 (0.60) | ALDH1A1F7F3SARM1SIRT2 | |
| SCHEMBL12309125 | 0.83 | ALDH1A1 (0.60) | ALDH1A1F7F3SARM1SIRT2 | |
| SCHEMBL20954559 | 0.80 | F7 (0.61) | ALDH1A1F7F3SARM1SIRT2 | |
| SCHEMBL1143779 | 0.80 | TSHR (0.50) | ALDH1A1LMNAHTTKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101475504-A | 2-acetyl-3-amino-3-aryl-acrylic acid esters and preparation thereof | UNIV SOOCHOW (CN) | 2009-07-08 | — | — | CN | disclosed |
| EP-1165543-B1 | PROCESS FOR PREPARING S-(R*,S*)] -$g(b) - 1- 1-OXO-3- (4-PIPERIDINYL) PROPYL] -3-PIPERIDINYL] CARBONYL] AMINO] -3- PYRIDINEPROPANOIC ACID AND DERIVATIVES | ORTHO MCNEIL PHARM INC (US) | 2003-06-04 | — | — | EP | disclosed |
| US-6515130-B1 | The invention relates to a process of preparing (S-(R*,S*))-beta -(((1-(1-oxo-3-(4-piperidinyl)propyl)-3-piperidinyl) carbonyl)amino)-3-pyridinepropanoic acid derivatives represented by the antagonists of the platelet fibrinogen | COHEN JUDITH H (US) | 2003-02-04 | — | — | US | disclosed |
| US-20020137937-A1 | Process for preparing [S- (R*, S*) ] -beta- [ [ [1- [1-oxo-3- (4-piperidinyl) propyl] -3-piperidinyl] carbonyl]amino] -3-pyridinepropanoic acid and derivatives | COHEN JUDITH H (US) | 2002-09-26 | — | — | US | disclosed |
| EP-1165543-A1 | PROCESS FOR PREPARING S-(R*,S*)] -$g(b) - 1- 1-OXO-3- (4-PIPERIDINYL) PROPYL] -3-PIPERIDINYL] CARBONYL] AMINO] -3- PYRIDINEPROPANOIC ACID AND DERIVATIVES | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000056730-A1 | PROCESS FOR PREPARING [S-(R*,S*)] -β -[[[1-[1-OXO-3- (4-PIPERIDINYL) PROPYL] -3-PIPERIDINYL] CARBONYL] AMINO] -3- PYRIDINEPROPANOIC ACID AND DERIVATIVES | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2000-09-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020137937-A1 | Process for preparing [S- (R*, S*) ] -beta- [ [ [1- [1-oxo-3- (4-piperidinyl) propyl] -3-piperidinyl] carbonyl]amino] -3-pyridinepropanoic acid and derivatives | GRHPR, SUCNR1, GABARAPL1 | ALDH1A1 217/4885F7 389/4885F3 2604/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.