Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6170001 | 0.89 | PTGS2 (0.53) | PTGS2HTTLMNAMAPK1RAB9A | |
| SCHEMBL3940426 | 0.85 | HTT (0.61) | HTTLMNAMAPK1RAB9ANPC1 | |
| SCHEMBL1347457 | 0.84 | HTT (0.68) | HTTLMNAMAPK1RAB9ATAS2R14 | |
| SCHEMBL1515704 | 0.82 | HTT (0.62) | HTTLMNAMAPK1RAB9ANPC1 | |
| SCHEMBL6167104 | 0.81 | HTT (0.52) | HTTLMNAMAPK1RAB9ANPC1 | |
| SCHEMBL29236666 | 0.79 | HTT (0.56) | HTTLMNAMAPK1RAB9ANPC1 | |
| SCHEMBL30969396 | 0.79 | HTT (0.56) | HTTLMNAMAPK1RAB9ANPC1 | |
| SCHEMBL8806348 | 0.78 | HTT (0.47) | PTGS2HTTLMNAMAPK1RAB9A | |
| SCHEMBL4772305 | 0.78 | PTGS2 (0.53) | PTGS2KMT2A | |
| SCHEMBL6970870 | 0.78 | PTGS2 (0.53) | PTGS2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115729-B1 | PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PTP-1B | MERCK FROSST CANADA INC (CA) | 2003-02-19 | — | — | EP | disclosed |
| US-6174874-B1 | ANTIDIABETIC,-CARCINOGENIC AGENTS; IMPROVING GLUCOSE TOLERANCE/INSULIN-SENSITIVITY; PREVENTING/TREATING OBESITY AND NEURODEGENERATIVE DISEASES; E.G. 1,3-BIS-((PHOSPHONODI-FLUOROMETHYL)PHENYL)-2-DICARBOXYPROPANE | MERCK FROSST CANADA & CO. (CA) | 2001-01-16 | — | — | US | disclosed |