Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 3/20 | 0.45 |
| ▸ | CA2 | P00918 | 3/20 | 0.45 |
| ▸ | CA9 | Q16790 | 3/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6170001 | 0.87 | PTGS2 (0.53) | HTTLMNAMAPK1RAB9APTGS1 | |
| SCHEMBL1515704 | 0.81 | HTT (0.62) | HTTLMNAMAPK1RAB9AACHE | |
| SCHEMBL3940426 | 0.81 | HTT (0.61) | HTTLMNAMAPK1RAB9AACHE | |
| SCHEMBL6948148 | 0.78 | PTGS2 (0.52) | HTTLMNAMAPK1RAB9APTGS2 | |
| SCHEMBL6171405 | 0.78 | KMT2A (0.50) | HTTLMNAMAPK1RAB9APTGS1 | |
| SCHEMBL29236666 | 0.75 | HTT (0.56) | HTTLMNAMAPK1RAB9AACHE | |
| SCHEMBL1347457 | 0.75 | HTT (0.68) | HTTLMNAMAPK1RAB9AACHE | |
| SCHEMBL30969396 | 0.75 | HTT (0.56) | HTTLMNAMAPK1RAB9AACHE | |
| SCHEMBL2121926 | 0.73 | PTGS2 (0.68) | PTGS1PTGS2CA1CA2CA9 | |
| SCHEMBL7217060 | 0.72 | PTGS1 (0.52) | HTTLMNAPTGS1PTGS2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0809636-A1 | SUBSTITUTED ISOXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-12-03 | — | — | EP | disclosed |
| WO-1996025405-A1 | SUBSTITUTED ISOXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-22 | — | — | WO | disclosed |