Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.36 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.34 |
| ▸ | ITK | Q08881 | 2/20 | 0.34 |
| ▸ | SGK1 | O00141 | 2/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | METAP1 | P53582 | 1/20 | 0.33 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30481668 | 0.79 | MAPK10 (0.39) | RIPK1MAPK10METAP2ITKSGK1 | |
| SCHEMBL14830830 | 0.79 | MAPK10 (0.39) | RIPK1MAPK10METAP2ITKSGK1 | |
| SCHEMBL31538744 | 0.73 | ALDH1A1 (0.51) | RIPK1MAPK10IMPDH2IMPDH1METAP2 | |
| SCHEMBL694559 | 0.72 | KDM4E (0.53) | METAP2 | |
| SCHEMBL16936902 | 0.71 | MAPK10 (0.42) | RIPK1MAPK10IMPDH2IMPDH1METAP2 | |
| SCHEMBL695962 | 0.71 | PLAU (0.39) | — | |
| SCHEMBL708360 | 0.70 | CCNE2 (0.36) | RIPK1MAPK10METAP2CYP11B2ITK | |
| SCHEMBL3683853 | 0.69 | METAP2 (0.46) | RIPK1MAPK10IMPDH2IMPDH1METAP2 | |
| SCHEMBL29740998 | 0.68 | TRPA1 (0.54) | RIPK1MAPK10IMPDH2IMPDH1METAP2 | |
| SCHEMBL774832 | 0.68 | TRPA1 (0.54) | RIPK1MAPK10IMPDH2IMPDH1METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421864-A1 | 1-PYRAZOLO[4,3-C]ISOQUINOLINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010122272-A1 | 1-PYRAZOLO[4,3-C]ISOQUINOLINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-10-28 | — | — | WO | disclosed |