Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 5/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 7/20 | 0.43 |
| ▸ | HTR2C | P28335 | 7/20 | 0.43 |
| ▸ | HTR2B | P41595 | 7/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10399612 | 0.75 | HTR2C (0.45) | MAOAHTR2AHTR2CHTR2BKMT2A | |
| SCHEMBL3162737 | 0.71 | HTR2A (0.74) | MAOATSHRCYP3A4MAPTHTR2A | |
| Hydrochloric Acid SCHEMBL4247274 | 0.70 | HTR2A (0.71) | MAOATSHRCYP3A4MAPTHTR2A | |
| Bicarbonate SCHEMBL11383469 | 0.68 | HTR2A (0.62) | MAOATSHRCYP3A4MAPTHTR2A | |
| SCHEMBL577943 | 0.68 | CYP3A4 (0.45) | MAOATSHRCYP3A4MAPTALDH1A1 | |
| SCHEMBL5458998 | 0.68 | CYP3A4 (0.41) | MAOATSHRCYP3A4MAPTALDH1A1 | |
| SCHEMBL14481557 | 0.67 | MAPT (0.68) | MAOATSHRCYP3A4MAPTHTR2A | |
| SCHEMBL2594537 | 0.67 | MAPT (0.68) | MAOATSHRCYP3A4MAPTHTR2A | |
| SCHEMBL29924708 | 0.67 | MAPT (0.68) | MAOATSHRCYP3A4MAPTHTR2A | |
| SCHEMBL329913 | 0.67 | HTR2A (0.61) | MAOATSHRCYP3A4MAPTHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204002-B1 | PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF TUMORS | INTERNATIONAL SOC FOR DRUG DEVELOPMENT S R L (IT) | 2021-05-19 | — | — | EP | claimed |
| CN-109761945-B | naringenin-O-alkylamine compound, preparation method and application | 南阳师范学院 | 2020-07-31 | — | — | CN | claimed |
| CN-109651321-B | apigenin-O-alkylamine compound, preparation method and application | 南阳师范学院 | 2020-06-26 | — | — | CN | claimed |
| US-20030073641-A1 | Novel N-(arylsulphonyl) amino acid derivatives, process for their preparation and pharmaceutical compositions containing them | SANOFI-AVENTIS (FR) | 2003-04-17 | — | — | US | claimed |
| US-20020115685-A1 | Novel N-(arylsulphonyl) amino acid derivatives, process for their preparation and pharmaceutical compositions containing them | SANOFI-AVENTIS (FR) | 2002-08-22 | — | — | US | claimed |
| EP-0877737-B1 | NOVEL N-(ARYLSULPHONYL)AMINO ACID DERIVATIVES HAVING BRADYKININ RECEPTOR AFFINITY | SANOFI SYNTHELABO (FR) | 2001-08-01 | — | — | EP | claimed |
| US-6025472-A | PEPTIDE ALDEHYDES WHICH ARE POTENT INHIBITORS OF FACTOR XA, USEFUL AS THERAPEUTIC AGENTS FOR DISEASE STATES IN MAMMALS CHARACTERIZED BY ABNORMAL THROMBOSIS | CORVAS INTERNATIONAL, INC. (US) | 2000-02-15 | — | — | US | claimed |
| US-5955576-A | PEPTIDE ALDEHYDE ANALOGS THAT INHIBIT THROMBIN OR FACTOR XA; FOR PREVENTION OR TREATMENT OF ABNORMAL THROMBOSIS | CORVAS INTERNATIONAL, INC. (US) | 1999-09-21 | — | — | US | claimed |
| EP-0765338-B1 | ARGININE MIMIC DERIVATIVES AS ENZYME INHIBITORS | CORVAS INT INC (US) | 1999-04-21 | — | — | EP | claimed |
| US-5883107-A | ANTITHROMBOTIC AGENTS | CORVAS INTERNATIONAL, INC. (US) | 1999-03-16 | — | — | US | claimed |
| EP-0877737-A1 | NOVEL N-(ARYLSULPHONYL)AMINO ACID DERIVATIVES HAVING BRADYKININ RECEPTOR AFFINITY | SANOFI (FR) | 1998-11-18 | — | — | EP | claimed |
| US-5696231-A | ANTICOAGULANTS; CARDIOVASCULAR DISORDERS | CORVAS INTERNATIONAL, INC. (US) | 1997-12-09 | — | — | US | claimed |
| WO-1997025315-A1 | NOVEL N-(ARYLSULPHONYL)AMINO ACID DERIVATIVES HAVING BRADYKININ RECEPTOR AFFINITY | SANOFI (FR) | 1997-07-17 | — | — | WO | claimed |
| US-5618814-A | Trisubstituted pyrimido [5,4-d] pyrimidines for modulating multi-drug resistance and pharmaceutical compositions containing these compounds | DR. KARL THOMAE GMBH (DE) | 1997-04-08 | — | — | US | claimed |
| WO-1996019493-A1 | N-SUBSTITUTED GLYCINE DERIVATIVES AS INHIBITORS OF FACTOR Xa | CORVAS INTERNATIONAL, INC. (US) | 1996-06-27 | — | — | WO | claimed |
| EP-0645390-A1 | Trisubstituted pyrimido 5,4-d pyrimidines for modulating multidrug resistance, drugs containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1995-03-29 | — | — | EP | claimed |
| US-4914092-A | ANTIULCER AGENTS | SYNTHELABO (FR) | 1990-04-03 | — | — | US | claimed |
| US-4487774-A | Isochromans | THE UPJOHN COMPANY (US) | 1984-12-11 | — | — | US | claimed |
| EP-3204002-B1 | PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF TUMORS | INTERNATIONAL SOC FOR DRUG DEVELOPMENT S R L (IT) | 2021-05-19 | — | — | EP | disclosed |
| US-4914092-A | ANTIULCER AGENTS | SYNTHELABO (FR) | 1990-04-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020115685-A1 | Novel N-(arylsulphonyl) amino acid derivatives, process for their preparation and pharmaceutical compositions containing them | CYP2C9, ADRM1, ADRA1D | MAOA 375/4885TSHR 2697/4885CYP3A4 74/4885 |
| US-20030073641-A1 | Novel N-(arylsulphonyl) amino acid derivatives, process for their preparation and pharmaceutical compositions containing them | CYP2C9, ADRM1, ADRA1D | MAOA 375/4885TSHR 2697/4885CYP3A4 74/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.