Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6949839 | 0.90 | CHEK1 (0.50) | BRD4CREBBPPARP1NPC1RAB9A | |
| SCHEMBL6946441 | 0.89 | PARP1 (0.48) | BRD4CREBBPPARP1NPC1RAB9A | |
| SCHEMBL6946473 | 0.88 | NPC1 (0.50) | BRD4CREBBPPARP1NPC1RAB9A | |
| SCHEMBL6948419 | 0.85 | PARP1 (0.45) | BRD4CREBBPPARP1NPC1RAB9A | |
| SCHEMBL6945364 | 0.83 | RAB9A (0.52) | BRD4CREBBPPARP1NPC1RAB9A | |
| SCHEMBL6948954 | 0.82 | NPC1 (0.55) | PARP1NPC1RAB9AKDM4EHDAC6 | |
| SCHEMBL6948273 | 0.82 | DHODH (0.51) | BRD4CREBBPPARP1ALDH1A1MAPT | |
| SCHEMBL6945300 | 0.81 | CHEK1 (0.48) | BRD4CREBBPPARP1MAPTHSD17B10 | |
| SCHEMBL6948946 | 0.81 | NPC1 (0.46) | BRD4CREBBPPARP1NPC1RAB9A | |
| SCHEMBL29412049 | 0.80 | PARP1 (0.60) | PARP1NPC1RAB9ADHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0936218-B1 | BENZIMIDAZOLE DERIVATIVES | MOCHIDA PHARM CO LTD (JP) | 2003-04-02 | — | — | EP | disclosed |
| US-6387938-B1 | Benzimidazole derivatives | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-05-14 | — | — | US | disclosed |
| EP-0936218-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1999-08-18 | — | — | EP | disclosed |