SCHEMBL6942886

SCHEMBL6942886

CCOC(=O)c1cccc2[nH]c(CCc3ccccc3)nc12

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 3/20 0.48
CHEK1 O14757 1/20 0.48
MAPT P10636 2/20 0.47
PRKD3 O94806 1/20 0.47
MAP4K4 O95819 1/20 0.47
PIM1 P11309 1/20 0.47
CLK2 P49760 1/20 0.47
MAP4K2 Q12851 1/20 0.47
CAMK2D Q13557 1/20 0.47
DYRK1A Q13627 1/20 0.47
PIM3 Q86V86 1/20 0.47
AURKB Q96GD4 1/20 0.47
PRKD2 Q9BZL6 1/20 0.47
CLK4 Q9HAZ1 1/20 0.47
STK17A Q9UEE5 1/20 0.47
MAP4K5 Q9Y4K4 1/20 0.47
NPC1 O15118 2/20 0.47
RAB9A P51151 2/20 0.47
TSHR P16473 2/20 0.47
CYP1A2 P05177 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6948956 0.91 DHODH (0.54) PARP1MAPTSMN1; SMN2
SCHEMBL6945407 0.89 LMNA (0.45) PARP1CHEK1MAPTPRKD3MAP4K4
SCHEMBL6949856 0.87 SCN1A (0.42) PARP1CHEK1MAPTPRKD3MAP4K4
SCHEMBL6949839 0.86 CHEK1 (0.50) PARP1CHEK1MAPTNPC1RAB9A
SCHEMBL6949858 0.86 CHEK1 (0.41) PARP1CHEK1MAPTPRKD3MAP4K4
SCHEMBL6945584 0.84 ALOX15 (0.48) MAPTNPC1RAB9ATSHRCYP1A2
SCHEMBL6945364 0.84 RAB9A (0.52) PARP1MAPTNPC1RAB9ASMN1; SMN2
SCHEMBL6948954 0.83 NPC1 (0.55) PARP1NPC1RAB9AKDM4E
SCHEMBL7485575 0.83 CHEK1 (0.52) PARP1CHEK1MAPTPRKD3MAP4K4
SCHEMBL29412049 0.81 PARP1 (0.60) PARP1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0936218-B1 BENZIMIDAZOLE DERIVATIVES MOCHIDA PHARM CO LTD (JP) 2003-04-02 EP disclosed
US-6387938-B1 Benzimidazole derivatives MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2002-05-14 US disclosed
EP-0936218-A1 NOVEL BENZIMIDAZOLE DERIVATIVES MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 1999-08-18 EP disclosed