Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.81 |
| ▸ | LMNA | P02545 | 1/20 | 0.77 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.77 |
| ▸ | MEN1 | O00255 | 2/20 | 0.77 |
| ▸ | HTT | P42858 | 2/20 | 0.76 |
| ▸ | PKM | P14618 | 1/20 | 0.76 |
| ▸ | GAA | P10253 | 1/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2476165 | 0.90 | ALDH1A1 (1.00) | ALDH1A1LMNAL3MBTL1KMT2AMEN1 | |
| SCHEMBL6237506 | 0.87 | ALDH1A1 (0.81) | ALDH1A1LMNAL3MBTL1KMT2AMEN1 | |
| SCHEMBL5251827 | 0.87 | ALDH1A1 (0.81) | ALDH1A1LMNAL3MBTL1KMT2AMEN1 | |
| SCHEMBL3339720 | 0.87 | KMT2A (1.00) | ALDH1A1LMNAL3MBTL1KMT2AMEN1 | |
| SCHEMBL7510989 | 0.86 | KMT2A (0.82) | ALDH1A1LMNAL3MBTL1KMT2AMEN1 | |
| SCHEMBL24071842 | 0.85 | RAB9A (0.84) | ALDH1A1KMT2AGAARAB9A | |
| SCHEMBL4714672 | 0.85 | LMNA (0.82) | ALDH1A1LMNAL3MBTL1KMT2AMEN1 | |
| SCHEMBL4710924 | 0.84 | ALDH1A1 (0.76) | ALDH1A1LMNAL3MBTL1KMT2AMEN1 | |
| SCHEMBL24072635 | 0.84 | RAB9A (0.76) | ALDH1A1LMNAL3MBTL1KMT2AMEN1 | |
| SCHEMBL18065567 | 0.82 | KMT2A (0.57) | ALDH1A1LMNAL3MBTL1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966462-B1 | HETEROCYCLIC COMPOUNDS USEFUL AS OXIDO-SQUALENE CYCLASE INHIBITORS | ASTRAZENECA AB (SE) | 2003-06-11 | — | — | EP | disclosed |
| EP-0925286-B1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ASTRAZENECA AB (SE) | 2003-01-02 | — | — | EP | disclosed |
| US-6391880-B1 | ANTICHOLESTEROL AGENTS | ZENECA LIMITED (GB) | 2002-05-21 | — | — | US | disclosed |
| US-6093718-A | AN OXIDO-SQUALENE CYCLASE INHIBITOR, ANTICHOLESTEROL AGENT FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND LOWERING CHOLESTEROL LEVELS IN BLOOD PLASMA; TREATING HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2000-07-25 | — | — | US | disclosed |
| EP-0966462-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS OXIDO-SQUALENE CYCLASE INHIBITORS | ZENECA LIMITED (GB) | 1999-12-29 | — | — | EP | disclosed |
| EP-0925286-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ZENECA LIMITED (GB) | 1999-06-30 | — | — | EP | disclosed |
| WO-1998035959-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS OXIDO-SQUALENE CYCLASE INHIBITORS | ZENECA LIMITED (GB) | 1998-08-20 | — | — | WO | disclosed |
| WO-1998006705-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ZENECA LIMITED (GB) | 1998-02-19 | — | — | WO | disclosed |