Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.35 |
| ▸ | PDE4A | P27815 | 4/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | PDE1A | P54750 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5776479 | 0.83 | PDE4B (0.35) | ALDH1A1KDM4EHPGDGBA1PDE4B | |
| SCHEMBL15647191 | 0.80 | ALDH1A1 (0.46) | ALDH1A1KDM4EHPGDGBA1PDE4B | |
| SCHEMBL6953358 | 0.77 | KDM4E (0.40) | ALDH1A1KDM4EHPGDPDE4BMAPKAPK2 | |
| SCHEMBL5774696 | 0.77 | IKBKB (0.41) | ALDH1A1KDM4EHPGDMAPKAPK2ADORA2A | |
| SCHEMBL7653423 | 0.74 | KMT2A (0.43) | ALDH1A1KDM4EPDE4BMAPKAPK2PDE4A | |
| SCHEMBL2418439 | 0.73 | MCHR1 (0.42) | ALDH1A1KDM4EHPGDPDE5APDE1A | |
| SCHEMBL5778419 | 0.73 | MAPKAPK2 (0.40) | ALDH1A1KDM4EHPGDGBA1MAPKAPK2 | |
| SCHEMBL5776551 | 0.72 | IKBKB (0.40) | ALDH1A1KDM4EHPGDMAPKAPK2ADORA2A | |
| SCHEMBL21474536 | 0.72 | ERBB2 (0.38) | ALDH1A1KDM4EHPGDGBA1ADORA2A | |
| SCHEMBL27368676 | 0.71 | ALDH1A1 (0.58) | ALDH1A1PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0887344-B1 | Quinolines and quinazolines useful in therapy | PFIZER LTD (GB) | 2003-12-03 | — | — | EP | disclosed |
| US-6417194-B1 | TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | PFIZER, INC. | 2002-07-09 | — | — | US | disclosed |
| US-6048864-A | Quinolines and quinazolines useful in therapy | PFIZER INC (US) | 2000-04-11 | — | — | US | disclosed |
| EP-0887344-A1 | Quinolines and quinazolines useful in therapy | Pfizer Limited (GB) | 1998-12-30 | — | — | EP | disclosed |