Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PDE9A | O76083 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | FPR2 | P25090 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6953358 | 0.97 | KDM4E (0.40) | KMT2AKDM4EMAPK1HSD17B10PDE9A | |
| SCHEMBL7655446 | 0.79 | KMT2A (0.41) | KMT2AKDM4EMAPK1HSD17B10PDE9A | |
| SCHEMBL6943425 | 0.77 | TUBB4A (0.39) | KMT2AKDM4EMAPK1HSD17B10MEN1 | |
| SCHEMBL6948732 | 0.74 | ALDH1A1 (0.36) | KDM4EMAPK1HSD17B10ADORA2AADORA1 | |
| SCHEMBL7651324 | 0.74 | PDE5A (0.45) | KMT2AKDM4EPDE4BALDH1A1FPR2 | |
| SCHEMBL6443434 | 0.72 | ADORA1 (0.58) | KDM4EMAPK1HSD17B10ADORA2AADORA1 | |
| SCHEMBL21823418 | 0.71 | FPR2 (0.46) | KMT2AMAPK1PDE9AMEN1PDE4B | |
| SCHEMBL6943414 | 0.71 | KDM4E (0.47) | KMT2AKDM4EHSD17B10PDE4BALDH1A1 | |
| SCHEMBL6954242 | 0.71 | AR (0.47) | KDM4EPDE4BALDH1A1FPR2USP2 | |
| SCHEMBL5749526 | 0.70 | ADORA2A (0.43) | KMT2AKDM4EMAPK1HSD17B10ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6417194-B1 | TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | PFIZER, INC. | 2002-07-09 | — | — | US | disclosed |
| US-6048864-A | Quinolines and quinazolines useful in therapy | PFIZER INC (US) | 2000-04-11 | — | — | US | disclosed |
| EP-0887344-A1 | Quinolines and quinazolines useful in therapy | Pfizer Limited (GB) | 1998-12-30 | — | — | EP | disclosed |