Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.37 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.35 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5774696 | 0.94 | IKBKB (0.41) | MAPKAPK2ALDH1A1KDM4EHPGDTSHR | |
| SCHEMBL5776551 | 0.92 | IKBKB (0.40) | MAPKAPK2ALDH1A1KDM4EHPGDTSHR | |
| SCHEMBL5772540 | 0.90 | MAPKAPK2 (0.39) | MAPKAPK2ALDH1A1KDM4EHPGDTSHR | |
| SCHEMBL5775046 | 0.81 | TRPV4 (0.35) | ALDH1A1KDM4EHPGDTSHRHSD17B10 | |
| SCHEMBL5776006 | 0.79 | CFTR (0.40) | MAPKAPK2ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL5773407 | 0.75 | IKBKB (0.36) | ALDH1A1TSHRIKBKBPOLBMAPK1 | |
| SCHEMBL15647191 | 0.74 | ALDH1A1 (0.46) | MAPKAPK2ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL5776290 | 0.74 | PTGDR2 (0.39) | ALDH1A1TSHRIKBKBMEN1KMT2A | |
| SCHEMBL6948732 | 0.73 | ALDH1A1 (0.36) | MAPKAPK2ALDH1A1KDM4EHPGDTSHR | |
| SCHEMBL1913634 | 0.73 | ALDH1A1 (0.49) | ALDH1A1KDM4EHPGDADORA1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1483257-B1 | QUINAZOLINE COMPOUNDS USEFUL IN THERAPY | PFIZER LTD (GB) | 2006-09-13 | — | — | EP | disclosed |
| US-6936619-B2 | Cardiovascular disorders; antilipemic agents; sexual disorders | PFIZER, INC. (US) | 2005-08-30 | — | — | US | disclosed |
| EP-1542677-A1 | COMBINATIONS OF ATORVASTATIN AND a1, ADRENERGIC RECEPTOR ANTA GONISTS | Pfizer Limited (GB) | 2005-06-22 | — | — | EP | disclosed |
| EP-1483257-A1 | QUINAZOLINE COMPOUNDS USEFUL IN THERAPY | Pfizer Limited (GB) | 2004-12-08 | — | — | EP | disclosed |
| US-20040132728-A1 | Combinations of atorvastatin and alpha1adrenergic receptor antagonists | PFIZER INC | 2004-07-08 | — | — | US | disclosed |
| WO-2004026300-A1 | COMBINATIONS OF ATORVASTATIN AND α1, ADRENERGIC RECEPTOR ANTAGONISTS | PFIZER LIMITED (GB) | 2004-04-01 | — | — | WO | disclosed |
| US-20040029859-A1 | Compounds useful in therapy | PFIZER INC. | 2004-02-12 | — | — | US | disclosed |
| WO-2003076427-A1 | QUINAZOLINE COMPOUNDS USEFUL IN THERAPY | PFIZER LIMITED (GB) | 2003-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040029859-A1 | Compounds useful in therapy | ADRA1D, HSD3B1, PTGER1 | MAPKAPK2 4313/4885ALDH1A1 1113/4885KDM4E 2413/4885 |
| US-20040132728-A1 | Combinations of atorvastatin and alpha1adrenergic receptor antagonists | ADRA1A, ADRA1D, ADRB1 | MAPKAPK2 2600/4885ALDH1A1 504/4885KDM4E 4766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.