Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6951613 | 0.88 | PGR (0.46) | MEN1KMT2AATMPGRSLC6A2 | |
| SCHEMBL8119434 | 0.83 | ALDH1A1 (0.46) | ALDH1A1 | |
| SCHEMBL6644290 | 0.82 | MEN1 (0.41) | MEN1KMT2AATMAPEX1ALDH1A1 | |
| SCHEMBL8565489 | 0.82 | MEN1 (0.44) | MEN1KMT2AATMAPEX1GAA | |
| SCHEMBL3301756 | 0.80 | TMEM97 (0.51) | MEN1KMT2ATMEM97SIGMAR1HTR3A | |
| SCHEMBL6947807 | 0.79 | ALDH1A1 (0.47) | PGRSLC6A2ALDH1A1 | |
| SCHEMBL6582840 | 0.76 | TMEM97 (0.53) | MEN1KMT2ATMEM97SIGMAR1HTR3A | |
| SCHEMBL6588314 | 0.76 | TMEM97 (0.50) | MEN1KMT2ATMEM97SIGMAR1HTR3A | |
| SCHEMBL4621924 | 0.75 | ALDH1A1 (0.59) | MEN1KMT2APGRSLC6A2SLC6A4 | |
| SCHEMBL6945702 | 0.71 | SLC6A2 (0.42) | HTR4SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1105388-B1 | N-SUBSTITUTED AZABICYCLOHEPTANE DERIVATIVES, PRODUCTION AND USE THEREOF | BASF AG (DE) | 2003-05-02 | — | — | EP | disclosed |
| US-6458821-B1 | THE NOVEL SUBSTANCES ARE SUITABLE FOR CONTROLLING DISEASES. INTERESTING PROPERTIES AS POTENTIAL NEUROLEPTICS AND ANTIDEPRESSANTS | ABBOTT LABORATORIES | 2002-10-01 | — | — | US | disclosed |