Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 15/20 | 0.52 |
| ▸ | MMP3 | P08254 | 8/20 | 0.52 |
| ▸ | MMP9 | P14780 | 7/20 | 0.52 |
| ▸ | MMP13 | P45452 | 6/20 | 0.52 |
| ▸ | MMP1 | P03956 | 10/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.35 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6952641 | 0.91 | MMP2 (0.44) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL6946800 | 0.86 | MMP2 (0.49) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL6949235 | 0.83 | MMP2 (0.43) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7080806 | 0.82 | MMP3 (0.51) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL6943124 | 0.78 | MMP2 (0.54) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL6946069 | 0.77 | MMP2 (0.41) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL6943312 | 0.77 | PLA2G7 (0.43) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL6943165 | 0.75 | MMP3 (0.46) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL6954462 | 0.74 | MMP3 (0.56) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL6952757 | 0.73 | MMP3 (0.48) | MMP2MMP3MMP9MMP13MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1030836-B1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY | DARWIN DISCOVERY LTD (GB) | 2003-01-29 | — | — | EP | claimed |