SCHEMBL6948936

SCHEMBL6948936

O=C(O)c1cc(Cl)[c]c(Cl)c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TPMT P51580 4/20 0.56
TTR P02766 2/20 0.52
HCAR1 Q9BXC0 1/20 0.48
CA12 O43570 2/20 0.46
CA1 P00915 2/20 0.46
CA2 P00918 2/20 0.46
CA7 P43166 2/20 0.46
CA9 Q16790 2/20 0.46
CA14 Q9ULX7 2/20 0.46
TSHR P16473 4/20 0.44
ALOX15 P16050 2/20 0.44
TP53 P04637 2/20 0.44
KDM4E B2RXH2 1/20 0.44
ALDH1A1 P00352 1/20 0.44
LMNA P02545 1/20 0.44
CA3 P07451 1/20 0.44
MAPT P10636 1/20 0.44
SELL P14151 1/20 0.44
HPGD P15428 1/20 0.44
SELP P16109 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22982 0.73 CA12 (0.65) TPMTTTRHCAR1CA12CA1
SCHEMBL26189 0.73 CA12 (0.65) TPMTTTRHCAR1CA12CA1
SCHEMBL28214359 0.72 TPMT (1.00) TPMTTTRHCAR1CA12CA1
SCHEMBL23699 0.72 TPMT (1.00) TPMTTTRHCAR1CA12CA1
SCHEMBL69625 0.72 TPMT (0.89) TPMTTTRHCAR1CA12CA1
SCHEMBL1205901 0.72 TSHR (0.48) TPMTTTRCA12CA1CA2
SCHEMBL1816269 0.72 CA1 (0.54) CA12CA1CA2CA7CA9
SCHEMBL1966098 0.72 ALDH1A1 (0.41) ALDH1A1LMNAMAPTHPGDSMN1; SMN2
SCHEMBL11556678 0.70 TTR (0.76) TPMTTTRHCAR1CA12CA1
Hydrochloric Acid SCHEMBL11742420 0.70 TPMT (0.84) TPMTTTRHCAR1CA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0923568-B9 NOVEL BENZOFURAN-4-CARBOXAMIDES ALTANA PHARMA AG (DE) 2003-08-13 EP claimed
EP-0923568-B1 NOVEL BENZOFURAN-4-CARBOXAMIDES ALTANA PHARMA AG (DE) 2002-12-11 EP claimed
EP-0923568-A1 NOVEL BENZOFURAN-4-CARBOXAMIDES Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 1999-06-23 EP claimed
WO-1998007715-A9 NOVEL BENZOFURAN-4-CARBOXAMIDES BYK GULDEN LOMBERG CHEM FAB (DE) 1999-04-29 WO claimed
WO-1998007715-A1 NOVEL BENZOFURAN-4-CARBOXAMIDES BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1998-02-26 WO claimed
US-4692529-A Method for synthesizing a magenta coupler by selectively etherifying 4-hydroxy-5-pyrazolone KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) 1987-09-08 US claimed
EP-0007991-A1 Substituted 2-phenylamino-imidazolines-(2), their acid addition salts, medicaments containing them and processes for their preparation C.H. BOEHRINGER SOHN (DE) 1980-02-20 EP claimed
EP-0923568-B9 NOVEL BENZOFURAN-4-CARBOXAMIDES ALTANA PHARMA AG (DE) 2003-08-13 EP disclosed
EP-0923568-B1 NOVEL BENZOFURAN-4-CARBOXAMIDES ALTANA PHARMA AG (DE) 2002-12-11 EP disclosed
US-6211203-B1 RESPIRATORY SYSTEM DISORDERS, ANTIINFLAMMATORY AGENTS, ENZYME INHIBITORS BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 2001-04-03 US disclosed
EP-0923568-A1 NOVEL BENZOFURAN-4-CARBOXAMIDES Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 1999-06-23 EP disclosed
WO-1998007715-A9 NOVEL BENZOFURAN-4-CARBOXAMIDES BYK GULDEN LOMBERG CHEM FAB (DE) 1999-04-29 WO disclosed
WO-1998007715-A1 NOVEL BENZOFURAN-4-CARBOXAMIDES BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1998-02-26 WO disclosed
US-5051342-A Sharpness, whiteness FUJI PHOTO FILM CO., LTD. (JP) 1991-09-24 US disclosed
US-4880726-A TRANSMITTING LIGHT THROUGH A BAND STOP FILTER; REDUCED COLOR MIXING FUJI PHOTO FILM CO., LTD. (JP) 1989-11-14 US disclosed
US-4692529-A Method for synthesizing a magenta coupler by selectively etherifying 4-hydroxy-5-pyrazolone KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) 1987-09-08 US disclosed
EP-0082732-A2 A blocked magenta dye forming coupler KONICA CORPORATION (JP) 1983-06-29 EP disclosed
EP-0007991-A1 Substituted 2-phenylamino-imidazolines-(2), their acid addition salts, medicaments containing them and processes for their preparation C.H. BOEHRINGER SOHN (DE) 1980-02-20 EP disclosed
EP-0007991-A1 Substituted 2-phenylamino-imidazolines-(2), their acid addition salts, medicaments containing them and processes for their preparation C.H. BOEHRINGER SOHN (DE) 1980-02-20 EP disclosed
US-3935015-A Silver halide color photographic materials containing 3-anilino-5-pyrazolane couplers FUJI PHOTO FILM CO., LTD. (JA) 1976-01-27 US disclosed