Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6637915 | 0.93 | CRHR1 (0.49) | CRHR1 | |
| SCHEMBL6951812 | 0.85 | CRHR1 (0.40) | CRHR1 | |
| SCHEMBL6951432 | 0.84 | CRHR1 (0.39) | CRHR1 | |
| SCHEMBL6950666 | 0.77 | CRHR1 (0.42) | CRHR1KDM4E | |
| SCHEMBL5599813 | 0.76 | CRHR1 (0.53) | CRHR1KDM4E | |
| SCHEMBL6638659 | 0.74 | CRHR1 (0.48) | CRHR1KDM4E | |
| SCHEMBL6955172 | 0.70 | CRHR1 (0.48) | CRHR1 | |
| SCHEMBL25831210 | 0.69 | PDE3B (0.42) | CRHR1KDM4E | |
| SCHEMBL5600092 | 0.68 | CRHR1 (0.57) | CRHR1 | |
| SCHEMBL6634034 | 0.67 | SYK (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0977737-B1 | CRF ANTAGONISTIC QUINO- AND QUINAZOLINES | JANSSEN PHARMACEUTICA NV (BE) | 2003-09-17 | — | — | EP | claimed |