Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 2/20 | 0.35 |
| ▸ | LATS1 | O95835 | 1/20 | 0.35 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | NQO2 | P16083 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6638659 | 0.93 | CRHR1 (0.48) | CRHR1ALDH1A1POLBKDM4EMEN1 | |
| SCHEMBL6949178 | 0.77 | CRHR1 (0.43) | CRHR1KDM4E | |
| SCHEMBL5599396 | 0.76 | CRHR1 (0.53) | CRHR1ALDH1A1POLBKDM4EMAPT | |
| SCHEMBL6637915 | 0.74 | CRHR1 (0.49) | CRHR1 | |
| SCHEMBL27471056 | 0.72 | ALDH1A1 (0.50) | ALDH1A1POLBKDM4EMAPTMEN1 | |
| SCHEMBL5790387 | 0.71 | CRHR1 (0.43) | CRHR1 | |
| SCHEMBL6955172 | 0.70 | CRHR1 (0.48) | CRHR1LATS1LATS2LMNA | |
| SCHEMBL5844686 | 0.68 | CRHR1 (0.86) | CRHR1 | |
| SCHEMBL5599426 | 0.68 | CRHR1 (0.57) | CRHR1MEN1KMT2A | |
| SCHEMBL5844839 | 0.68 | CRHR1 (0.68) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0977737-B1 | CRF ANTAGONISTIC QUINO- AND QUINAZOLINES | JANSSEN PHARMACEUTICA NV (BE) | 2003-09-17 | — | — | EP | claimed |