Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 16/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TERT | O14746 | 1/20 | 0.37 |
| ▸ | LATS1 | O95835 | 1/20 | 0.36 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6953786 | 0.94 | CRHR1 (0.54) | CRHR1 | |
| SCHEMBL6947769 | 0.92 | CRHR1 (0.61) | CRHR1 | |
| SCHEMBL6607044 | 0.76 | NQO2 (0.52) | CRHR1LMNATERTLATS1LATS2 | |
| SCHEMBL6618425 | 0.75 | TERT (0.39) | CRHR1LMNATERTLATS1LATS2 | |
| SCHEMBL6637915 | 0.74 | CRHR1 (0.49) | CRHR1 | |
| SCHEMBL6638659 | 0.74 | CRHR1 (0.48) | CRHR1LMNATERT | |
| SCHEMBL5600109 | 0.73 | CRHR1 (0.83) | CRHR1 | |
| SCHEMBL6949178 | 0.70 | CRHR1 (0.43) | CRHR1 | |
| SCHEMBL6950666 | 0.70 | CRHR1 (0.42) | CRHR1LMNALATS1LATS2 | |
| SCHEMBL6600636 | 0.69 | HTT (0.53) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0977737-B1 | CRF ANTAGONISTIC QUINO- AND QUINAZOLINES | JANSSEN PHARMACEUTICA NV (BE) | 2003-09-17 | — | — | EP | claimed |