Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MME | P08473 | 2/20 | 0.37 |
| ▸ | ACE | P12821 | 2/20 | 0.37 |
| ▸ | CPA1 | P15085 | 2/20 | 0.37 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9346838 | 0.84 | EPHX1 (0.43) | SIGMAR1EPHX1MMEACECPA1 | |
| SCHEMBL16191154 | 0.80 | TDP1 (0.43) | TDP1EPHX2SIGMAR1 | |
| SCHEMBL522762 | 0.80 | ALDH1A1 (0.47) | TDP1EPHX2SIGMAR1EPHX1ALDH1A1 | |
| SCHEMBL7368102 | 0.80 | EPHX1 (0.46) | TDP1SIGMAR1EPHX1SLC6A2SLC6A4 | |
| SCHEMBL7492155 | 0.78 | TRPA1 (0.44) | TDP1HPGDALDH1A1MMEACE | |
| SCHEMBL7496228 | 0.78 | TRPA1 (0.44) | TDP1HPGDALDH1A1MMEACE | |
| SCHEMBL31117977 | 0.78 | EPHX1 (0.42) | SIGMAR1EPHX1ALDH1A1SLC6A2SLC6A4 | |
| SCHEMBL6031710 | 0.77 | EPHX1 (0.40) | TDP1SMN1; SMN2HPGDEPHX2EPHX1 | |
| SCHEMBL11868464 | 0.76 | EPHX1 (0.43) | TDP1EPHX2SIGMAR1EPHX1MME | |
| SCHEMBL28897690 | 0.76 | SIGMAR1 (0.43) | TDP1EPHX2SIGMAR1MMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268433-A1 | CYCLIC LACTAMS AS INHIBITORS OF A-BETA-PROTEIN PRODUCTION | Bristol-Myers Squibb Pharma Company (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001074783-A1 | CYCLIC LACTAMS AS INHIBITORS OF A ΒΕΤΑ PROTEIN PRODUCTION | DUPONT PHARMACEUTICALS COMPANY (US) | 2001-10-11 | — | — | WO | disclosed |