SCHEMBL6949952

SCHEMBL6949952

O=[N+]([O-])c1cc(Oc2nccnc2Cl)c(Cl)cc1F

nearest known ligand 0.42

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PIN1 Q13526 6/20 0.42
ALDH1A1 P00352 3/20 0.40
MAPT P10636 3/20 0.37
GFER P55789 1/20 0.37
ESPL1 Q14674 1/20 0.35
S1PR4 O95977 2/20 0.35
ATM Q13315 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
HIF1A Q16665 1/20 0.34
KDM4E B2RXH2 1/20 0.34
CYP3A4 P08684 1/20 0.34
ALOX15 P16050 1/20 0.34
PRKDC P78527 1/20 0.34
HSD17B10 Q99714 1/20 0.34
HPGD P15428 1/20 0.34
GAA P10253 1/20 0.34
HSPB1 P04792 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6949963 0.84 ALDH1A1 (0.43) PIN1ALDH1A1MAPTGFERS1PR4
SCHEMBL27581359 0.79 PIN1 (0.39) PIN1ALDH1A1MAPTGFERS1PR4
SCHEMBL193774 0.77 ALDH1A1 (0.47) ALDH1A1MAPTESPL1ATMTDP1
SCHEMBL30127220 0.77 ALDH1A1 (0.47) ALDH1A1MAPTESPL1ATMTDP1
SCHEMBL9632914 0.75 MERTK (0.49) ALDH1A1MAPTGFERTDP1HPGD
SCHEMBL7023377 0.75 ALDH1A1 (0.56) PIN1ALDH1A1MAPTGFERATM
SCHEMBL8877173 0.74 S1PR4 (0.39) PIN1ALDH1A1MAPTESPL1S1PR4
SCHEMBL9445017 0.74 S1PR4 (0.45) ALDH1A1MAPTS1PR4CYP3A4HPGD
SCHEMBL9775686 0.74 PDK1 (0.48) ALDH1A1MAPTESPL1S1PR4ATM
SCHEMBL21034914 0.73 MEN1 (0.43) PIN1ALDH1A1MAPTGFERTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1144380-A4 A META-NITRO PHENOL DERIVATIVE AND A PROCESS FOR PRODUCING IT ISHIHARA SANGYO KAISHA (JP) 2003-11-26 EP disclosed
CN-1376145-A A meta-nitro phenol derivative and a process for producing it ISHIHARA SANGYO KAISHA (JP) 2002-10-23 CN disclosed
EP-1144380-A1 A META-NITRO PHENOL DERIVATIVE AND A PROCESS FOR PRODUCING IT ISHIHARA SANGYO KAISHA, LTD. (JP) 2001-10-17 EP disclosed
WO-2000032573-A1 A META-NITRO PHENOL DERIVATIVE AND A PROCESS FOR PRODUCING IT ISHIHARA SANGYO KAISHA, LTD. (JP) 2000-06-08 WO disclosed