Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.49 |
| ▸ | LTA4H | P09960 | 2/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6947479 | 0.85 | OPRM1 (0.59) | OPRM1OPRD1HRH3SLC6A2 | |
| SCHEMBL7405793 | 0.81 | SIGMAR1 (0.69) | LTA4HHRH3HTTKMT2ASLC6A2 | |
| Hydrochloric Acid SCHEMBL7406707 | 0.80 | SIGMAR1 (0.67) | LTA4HHRH3HTTKMT2A | |
| SCHEMBL6944676 | 0.78 | TMEM97 (0.52) | OPRM1OPRD1LTA4H | |
| SCHEMBL7406987 | 0.76 | SIGMAR1 (0.62) | LTA4HHRH3HTTKMT2ASLC6A2 | |
| SCHEMBL7406694 | 0.75 | CCR3 (0.74) | LTA4HHRH3 | |
| Hydrochloric Acid SCHEMBL7397629 | 0.75 | SIGMAR1 (0.60) | LTA4HHRH3KMT2ASLC6A2 | |
| SCHEMBL7074517 | 0.75 | HRH3 (0.42) | OPRM1OPRD1HRH3SLC6A2 | |
| SCHEMBL6945365 | 0.74 | DRD3 (0.46) | OPRM1OPRD1 | |
| Hydrochloric Acid SCHEMBL7403110 | 0.74 | CCR3 (0.72) | LTA4HHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244450-A4 | 8-AZA-BICYCLO[3.2.1]OCTANE NMDA/NR2B ANTAGONISTS | MERCK & CO INC (US) | 2003-03-19 | — | — | EP | disclosed |
| EP-1244450-A1 | 8-AZA-BICYCLO[3.2.1]OCTANE NMDA/NR2B ANTAGONISTS | Merck & Co., Inc. (US) | 2002-10-02 | — | — | EP | disclosed |
| US-6432976-B1 | ANALGESICS; SIDE EFFECT REDUCTION | MERCK & CO., INC. | 2002-08-13 | — | — | US | disclosed |
| WO-2001032179-A1 | 8-AZA-BICYCLO[3.2.1]OCTANE NMDA/NR2B ANTAGONISTS | MERCK & CO., INC. (US) | 2001-05-10 | — | — | WO | disclosed |