Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 7/20 | 0.41 |
| ▸ | MMP9 | P14780 | 6/20 | 0.41 |
| ▸ | PPARA | Q07869 | 5/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
| ▸ | MMP16 | P51512 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6943326 | 0.88 | PPARA (0.41) | PPARAALDH1A1CYP1A2CYP3A4MEN1 | |
| SCHEMBL6946985 | 0.85 | PPARA (0.38) | PPARAALDH1A1CYP1A2CYP3A4MEN1 | |
| SCHEMBL6947449 | 0.81 | HRH3 (0.46) | MMP2MMP9MMP1MMP3MMP8 | |
| SCHEMBL6946992 | 0.70 | PPARA (0.40) | PPARAALDH1A1CYP1A2CYP3A4MEN1 | |
| SCHEMBL7078124 | 0.70 | MEN1 (0.44) | MMP2MMP9PPARAMMP1MMP3 | |
| SCHEMBL6947259 | 0.68 | CYP1A2 (0.43) | PPARAALDH1A1CYP1A2CYP3A4MEN1 | |
| SCHEMBL6946483 | 0.68 | MEN1 (0.46) | PPARAALDH1A1CYP1A2CYP3A4MEN1 | |
| SCHEMBL6946989 | 0.67 | PPARA (0.39) | PPARAALDH1A1CYP1A2CYP3A4MEN1 | |
| SCHEMBL6948494 | 0.63 | MEN1 (0.43) | PPARACYP1A2CYP3A4MEN1CYP2C19 | |
| SCHEMBL14558201 | 0.62 | KMT2A (0.46) | ALDH1A1KMT2ACA1CA2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1030836-B1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY | DARWIN DISCOVERY LTD (GB) | 2003-01-29 | — | — | EP | claimed |