Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 7/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 4/20 | 0.34 |
| ▸ | PPARG | P37231 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6943326 | 0.88 | PPARA (0.41) | PPARACYP3A4CYP1A2PMP22ABCB11 | |
| SCHEMBL6950101 | 0.85 | MMP2 (0.41) | PPARACYP3A4CYP1A2PMP22ABCB11 | |
| SCHEMBL6947259 | 0.83 | CYP1A2 (0.43) | PPARACYP3A4CYP1A2PMP22CYP2C19 | |
| SCHEMBL6946989 | 0.78 | PPARA (0.39) | PPARACYP3A4CYP1A2PMP22ABCB11 | |
| SCHEMBL6946992 | 0.77 | PPARA (0.40) | PPARACYP3A4CYP1A2PMP22ABCB11 | |
| SCHEMBL6946483 | 0.68 | MEN1 (0.46) | PPARACYP3A4CYP1A2PMP22CYP2C19 | |
| SCHEMBL7239714 | 0.67 | PROKR1 (0.41) | CYP3A4CYP1A2TSHRCYP2C19CYP2D6 | |
| SCHEMBL4611345 | 0.66 | CA12 (0.35) | CYP2D6KMT2ALMNA | |
| SCHEMBL6947449 | 0.65 | HRH3 (0.46) | CYP3A4CYP1A2PMP22CYP2C19MEN1 | |
| SCHEMBL7134517 | 0.65 | PPARA (0.40) | PPARACYP3A4CYP1A2PMP22ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1030836-B1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY | DARWIN DISCOVERY LTD (GB) | 2003-01-29 | — | — | EP | claimed |