Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 6/20 | 0.44 |
| ▸ | MMP2 | P08253 | 5/20 | 0.44 |
| ▸ | MMP13 | P45452 | 4/20 | 0.42 |
| ▸ | MMP8 | P22894 | 3/20 | 0.42 |
| ▸ | MMP1 | P03956 | 2/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
| ▸ | MMP16 | P51512 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6946483 | 0.87 | MEN1 (0.46) | HRH3CYP1A2CYP3A4CYP2C19BLM | |
| SCHEMBL6947259 | 0.83 | CYP1A2 (0.43) | HRH3CYP1A2CYP3A4CYP2C19BLM | |
| SCHEMBL7078124 | 0.81 | MEN1 (0.44) | MMP9MMP2MMP13MMP8MMP1 | |
| SCHEMBL6950101 | 0.81 | MMP2 (0.41) | MMP9MMP2MMP13MMP8MMP1 | |
| SCHEMBL6948494 | 0.78 | MEN1 (0.43) | HRH3CYP1A2CYP3A4CYP2C19BLM | |
| SCHEMBL6946800 | 0.72 | MMP2 (0.49) | HRH3MMP9MMP2MMP13MMP1 | |
| SCHEMBL6948498 | 0.71 | MEN1 (0.43) | HRH3CYP1A2CYP3A4CYP2C19BLM | |
| SCHEMBL6945635 | 0.70 | MMP13 (0.59) | MMP9MMP2MMP13MMP8MMP1 | |
| SCHEMBL7484970 | 0.68 | MEN1 (0.47) | HRH3CYP1A2CYP3A4CYP2C19BLM | |
| SCHEMBL7077695 | 0.68 | HDAC1 (0.44) | MMP9MMP2MMP13MMP8MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1030836-B1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY | DARWIN DISCOVERY LTD (GB) | 2003-01-29 | — | — | EP | claimed |