Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6943129 | 1.00 | TP53 (0.47) | TP53PARP1PARP3ALDH1A1MEN1 | |
| SCHEMBL29828622 | 0.84 | CHEK1 (0.48) | ALDH1A1RAB9AMMP2 | |
| SCHEMBL6945277 | 0.84 | CHEK1 (0.48) | ALDH1A1RAB9AMMP2 | |
| SCHEMBL6953837 | 0.84 | CHEK1 (0.43) | ALDH1A1POLBRAB9AMMP2RXFP1 | |
| SCHEMBL6945574 | 0.81 | CHEK1 (0.46) | ALDH1A1KMT2ARAB9AMMP2 | |
| SCHEMBL6952443 | 0.80 | BRD4 (0.46) | PARP1ALDH1A1RAB9AMMP2 | |
| SCHEMBL7653156 | 0.79 | ALDH1A1 (0.42) | PARP1ALDH1A1RAB9AMMP2 | |
| SCHEMBL529009 | 0.79 | RAB9A (0.48) | ALDH1A1RAB9A | |
| SCHEMBL6950391 | 0.77 | CHEK1 (0.52) | PARP1ALDH1A1RAB9AMMP2 | |
| SCHEMBL7654820 | 0.77 | ALDH1A1 (0.50) | ALDH1A1MEN1KMT2APOLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0936218-B1 | BENZIMIDAZOLE DERIVATIVES | MOCHIDA PHARM CO LTD (JP) | 2003-04-02 | — | — | EP | disclosed |
| US-6387938-B1 | Benzimidazole derivatives | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-05-14 | — | — | US | disclosed |
| EP-0936218-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1999-08-18 | — | — | EP | disclosed |