Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT8 | Q9H7Z6 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 7/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6950175 | 1.00 | KAT8 (0.42) | KAT8CA1CA2CA9ALDH1A1 | |
| SCHEMBL8427562 | 0.95 | KAT8 (0.41) | KAT8CA1CA2CA9ALDH1A1 | |
| SCHEMBL8427563 | 0.95 | KAT8 (0.41) | KAT8CA1CA2CA9ALDH1A1 | |
| SCHEMBL6951766 | 0.87 | PTGS2 (0.47) | KAT8CA1CA2CA9ALDH1A1 | |
| SCHEMBL8009451 | 0.87 | PTGS2 (0.47) | KAT8CA1CA2CA9ALDH1A1 | |
| SCHEMBL6947265 | 0.85 | KAT8 (0.42) | KAT8CA1CA2CA9ALDH1A1 | |
| SCHEMBL6947262 | 0.85 | KAT8 (0.42) | KAT8CA1CA2CA9ALDH1A1 | |
| SCHEMBL6951498 | 0.83 | L3MBTL1 (0.54) | ALDH1A1KDM4EMAPTMAPK1L3MBTL1 | |
| SCHEMBL6951495 | 0.83 | L3MBTL1 (0.54) | ALDH1A1KDM4EMAPTMAPK1L3MBTL1 | |
| SCHEMBL8428159 | 0.82 | PTGS2 (0.46) | KAT8CA1CA2CA9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743304-B1 | 4-(Arylaminomethylene)-2,4-dihydro-pyrazol-3-ones | MERCK PATENT GMBH (DE) | 2003-03-26 | — | — | EP | claimed |
| US-6034099-A | Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones | CELL PATHWAYS, INC. (US) | 2000-03-07 | — | — | US | claimed |
| EP-0743304-A1 | 4-(Arylaminomethylene)-2,4-dihydro-pyrazol-3-ones | MERCK PATENT GmbH (DE) | 1996-11-20 | — | — | EP | claimed |
| EP-0743304-B1 | 4-(Arylaminomethylene)-2,4-dihydro-pyrazol-3-ones | MERCK PATENT GMBH (DE) | 2003-03-26 | — | — | EP | disclosed |
| US-6034099-A | Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones | CELL PATHWAYS, INC. (US) | 2000-03-07 | — | — | US | disclosed |
| EP-0930881-A1 | PYRAZOLINONES TO TREAT DISTURBANCES OF POTENCY | MERCK PATENT GmbH (DE) | 1999-07-28 | — | — | EP | disclosed |
| US-5869516-A | 4-(arylaminomethylene)-2,4-dihydro-3-pyrazolones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-02-09 | — | — | US | disclosed |
| WO-1998016224-A1 | PYRAZOLINONES TO TREAT DISTURBANCES OF POTENCY | MERCK PATENT GMBH (DE) | 1998-04-23 | — | — | WO | disclosed |
| EP-0743304-A1 | 4-(Arylaminomethylene)-2,4-dihydro-pyrazol-3-ones | MERCK PATENT GmbH (DE) | 1996-11-20 | — | — | EP | disclosed |