Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 13/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 12/20 | 0.46 |
| ▸ | ITGAV | P06756 | 4/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD5 | P21918 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6946919 | 0.89 | ITGB3 (0.49) | ITGB3ITGA2BDRD2OPRM1HRH4 | |
| SCHEMBL6942397 | 0.85 | ITGB3 (0.51) | ITGB3ITGA2BOPRM1HRH4 | |
| SCHEMBL6951463 | 0.82 | ITGB3 (0.44) | ITGB3ITGA2BITGAV | |
| SCHEMBL7445038 | 0.79 | ITGB3 (0.46) | ITGB3ITGA2BDRD4OPRM1HRH4 | |
| SCHEMBL6419435 | 0.74 | ITGB3 (0.55) | ITGB3ITGA2BITGAV | |
| SCHEMBL6419432 | 0.74 | ITGB3 (0.55) | ITGB3ITGA2BITGAV | |
| SCHEMBL7445303 | 0.73 | DRD2 (0.41) | ITGB3ITGA2BITGAVDRD2DRD3 | |
| SCHEMBL6678596 | 0.71 | ITGB3 (0.63) | ITGB3ITGA2B | |
| SCHEMBL6678603 | 0.71 | ITGB3 (0.63) | ITGB3ITGA2B | |
| SCHEMBL6675207 | 0.71 | ITGB3 (0.67) | ITGB3ITGA2BITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674623-B1 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-04-09 | — | — | EP | disclosed |
| US-6403578-B1 | ANTICOAGULANTS, CARDIOVASCULAR DISORDERS | SMITHKLINE BEECHAM CORPORATION | 2002-06-11 | — | — | US | disclosed |
| EP-0674623-A1 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994014776-A2 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-07-07 | — | — | WO | disclosed |